Dacarbazine review

Dacarbazine is a drug used for the treatment of cancer. An alkylating agent, Dacarbazine is administered either through intravenous infusion or injection.

Dacarbazine is marketed under the brand names DTIC-Dome, DIC, DTIC, and Imidazole Carboxamide. It is recommended to patients of metastatic malignant melanoma, fibrosarcomas, soft tissue sarcomas, rhabdomyosarcoma, neuroblastoma, islet cell carcinoma, and carcinoma of the thyroid.

Dacarbazine can be administered intravenously through cannula usually at the back of a hand, or through a thin plastic tube placed beneath the skin and into a vein close to the collarbone. It can also be administered through a thin tube placed into a vein of the PICC line, or by infusion via the cannula. Such infusion normally takes 30 minutes up to 2 hours.

The length of the Chemotherapy and the number of treatment cycles depends on the kind of cancer being treated. It is also normal for Dacarbazine to be taken along with other chemotherapy medications.

The amount of Dacarbazine administered depends on numerous factors such as the overall health of the patient, and the type of condition being treated.

Patients should be informed that their reaction to Dacarbazine might differ from those of other patients. Some patients experience minimal side effects, while some experience more.

Users of Dacarbazine may feel sick while using the medication. Nausea and vomiting may become apparent a couple of hours after administration of the medicine. It can last for several days. Doctors usually prescribe anti-emetic medications to reduce these symptoms.

Dacarbazine can also lessen the bone marrow’s production of white blood cells. This would result to a patient becoming more susceptible to infections. This side effect can become apparent a week after administration of Dacarbazine. After a few weeks, the number of white blood cells will steadily increase.

Dacarbazine can also lessen the number of platelets in the body, which leads to unexplained bleeding or bruising. Patients may suffer from blood spots, nosebleeds, and bleeding gums as a result.

Users of Dacarbazine may also experience a decreased production of red blood cells or anemia. This usually makes patients feel exhausted and breathless.

Dacarbazine may also lead to patients losing their appetite and experience abnormal hair loss. Other unlikely side effects include diarrhea, sensitivity to sunlight, pain on the injected area, sore ulcers, and flu-like symptoms.

Patients should immediately inform their doctors if these side effects persist or worsen.

Before taking Dacarbazine, patients should inform their physicians of medications that they are taking, whether prescription or non-prescription types or herbal drugs. Patients should also not use drugs containing aspirin unless given approval by doctors.

It is also not safe for patients to take any sort of immunization while taking Dacarbazine.

Dacarbazine may also affect fertility of the patient. Patients should discuss this with their doctors before beginning to take the medication. It is also not advisable for patients to breast feed while using Dacarbazine since it may be passed on to the infant.

Dacarbazine has the following structural formula:

Chemical structure of dacarbazine

• Molecular formula of dacarbazine is C6H10N6O
• Chemical IUPAC Name is 5-dimethylaminoazo-3H-imidazole-4-carboxamide
• Molecular weight is 182.183 g/mol
Dacarbazine available : 100mg tablets and 200mg tablets

Brand name(s): Biocarbazine R, Dacarbazino, Dacarbazinum, Deticene, Imidazole Carboxamide

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