Dactinomycin review

Dactinomycin is a medication for the treatment of various types of cancer such as testicular and sarcomas. It belongs to a group of cancer-fighting drugs called antibiotics which stops the growth of cancer cells in the body.

Dactinomycin is available under the brand names Act-D, Actinomycin D, and Cosmegen. It is commonly prescribed to children, although adults may also be prescribed with this medication. Dactinomycin is particularly tapped for treatment of cancers of the soft tissue and bones particularly tendons and muscles, tumors in the womb, and cancer of the testicles.

Dactinomycin is injected in a vein for over 15 minutes. Patients are usually given a medicine prior to the administration of Dactinomycin to stop any vomiting or nausea once the drug is administered.

The dosage of Dactinomycin depends on the size and blood count of the patient as well as the condition of the cancer being treated. Blood counts of patients are taken before treatment of Dactinomycin. In case results of lab work indicate unsafe conditions, the treatment of Dactinomycin is delayed.

It is usual for patients to take Dactinomycin with other chemotherapy dugs.

Dactinomycin can decrease the amount of white blood cells in the body, particularly weeks after the administration of the medication. This can increase the patient’s risk of infection. Patients should immediately inform their doctors if they noticed possible symptoms of infection like high fever, pain when urinating, chills, or coughs.

Dactinomycin can lower the platelet count of the body a few weeks after being used, increasing the patient’s risk of bleeding. Patients should notify their physicians if they noticed unexplained bleeding like nosebleeds, tarry stools, or bleeding gums.

There is also a risk that Dactinomycin will decrease the amount of red blood cells in the body. Known as anemia, decreased red blood cell count results to difficulty in breathing, and exhaustion. Doctors may give medicines to prevent this condition. Alternatively, patients may need to have blood transfusion.

Patients should not take any vaccination while taking this medication without the approval of a physician. Dactinomycin can affect a patient’s immune system which can affect the effectiveness of vaccinations. Worse, this can also lead to severe infections.

Patients may also feel sick after receiving Dactinomycin. Doctors usually prescribed anti-nausea drugs to treat nausea and vomiting.

Dactinomycin can also result to rapid hair loss. However this is a temporary side effect, and the hair normally grows back after the treatment period.

Patients should inform their doctors of their medical history especially if they have had liver, kidney, heart diseases, diabetes, heart failure, gout, kidney stones, and infections. These conditions can have the dosage and timing of Dactinomycin changed accordingly.

Those who have been treated with radiation are usually given decreased dosages of Dactinomycin.

This drug can also have an effect on the fertility of its users. It can also cause birth defects especially if the mother took Dactinomycin during pregnancy or conception. Those who are taking Dactinomycin should use birth control to lessen risks of conception.

Dactinomycin has the following structural formula:

Chemical structure of dactinomycin

• Molecular formula of dactinomycin is C62H86N12O16
• Chemical IUPAC Name is 8-amino-N-(2-amino-4,6-dimethyl-3-oxo-phenoxazin-1-yl) carbonyl-N'- [8-amino-4,6-dimethyl-7-oxo-9-[[3,6,10-trimethyl-7,14-bis (1-methylethyl)-2,5,8,12,15- pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl] carbamoyl]phenoxazin-1-yl] carbonyl-4,6-dimethyl-7-oxo-N,N'-bis[3,6,10-trimethyl-7,14-bis (1-methylethyl)-2,5,8,12,15- pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]- 1,9-bis[[3,6,10-trimethyl-7,14- bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16- tetrazabicyclo[14.3.0]nonadec-11-yl] carbamoyl]phenoxazine-1,9-dicarboxamide
• Molecular weight is 1255.42 g/mol
Dactinomycin available : 0,5mg injection

Brand name(s): Cosmegen, Dactinomicina, Dactinomycine, Dactinomycinum, Lyovac Cosmegen, Meractinomycin, Oncostatin K, Oxamide

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