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Dactinomycine

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Dactinomycine

Dactinomycine review





Dactinomycine is a medication used in the treatment of various types of cancer including testicular and sarcomas. It belongs to a group of cancer-fighting medicaments, antibiotics, that stop the growth of cancer cells in the eubstance.

DACTINOMYCINE ACTION

Dactinomycine is available under the brand names Act-D and Actinomycin D. It is commonly prescribed to children, but adults may also be prescribed this medication. Dactinomycine is intended for the treatment of cancers of the soft tissue and bones particularly tendons and muscles, tumors in the womb, and cancer of the testicles.

Dactinomycine is injected in a vein for over 15 minutes. Patients are usually given a medicine prior to Dactinomycine to stop any vomiting or nausea once the medication is administered.

DACTINOMYCINE DOSAGE

The dosage of Dactinomycine will depend on the affected role's size, blood count, condition and the cancer being treated. Blood counts are taken before treatment of Dactinomycine. In case the lab tests indicate unsafe conditions, the treatment of Dactinomycine will be delayed.

It is usual for affected roles to take Dactinomycine with other chemotherapy dugs.

DACTINOMYCINE SIDE EFFECTS

Dactinomycine can decrease the amount of white blood cells in the eubstance for weeks after treatment has ended, which can increase the affected role's risk of infection. Patients should immediately inform their doctors if they experience symptoms of an infection like high fever, pain when urinating, chills, or coughs.

Dactinomycine can lower the platelet count of the affected role for a few weeks after being used, increasing the affected role's risk of bleeding. Patients should notify their physician if they experience unexplained bleeding including nosebleeds, tarry stools, or bleeding gums.

There is a risk that Dactinomycine will decrease the amount of red blood cells in the eubstance. Anemia, a decreased red blood cell count, results in difficulty in breathing, and exhaustion. Your doctor may prescribe additional medicines to prevent this condition or the affected role may need to have a blood transfusion.

Patients should not have any vaccinations while taking this medication without the prior approval of their physician. Dactinomycine can affect a affected role's immune system, which can alter the effectiveness of vaccinations and can lead to severe infections.

DACTINOMYCINE PRECAUTIONS

Patients may feel sick after taking Dactinomycine so doctors usually prescribed anti-nausea medicaments to treat nausea and vomiting.

Dactinomycine can also result in rapid baldness. However, this is a temporary side effect and the hair normally grows back after the treatment period.

Patients should inform their doctor of their medical history, especially if they have had liver, kidney, heart diseases, diabetes, heart failure, gout, kidney stones, and infections. These conditions may require the dosage and timing of Dactinomycine to be changed accordingly.

Those who have been treated with radiation are usually given decreased dosages of Dactinomycine.

DACTINOMYCINE DURING PREGNANCY

This medication can also have an effect on the fertility of its users. It can also cause birth defects, especially if the mother took Dactinomycine during pregnancy or conception. Those who are taking Dactinomycine should use birth control to lessen risks of conception.

Dactinomycine has the following structural formula:

Chemical structure of dactinomycine


 Molecular formula of dactinomycine is C62H86N12O16
 Chemical IUPAC Name is 8-amino-N-(2-amino-4,6-dimethyl-3-oxo-phenoxazin-1-yl)carbonyl-N'-[8-amino-4,6-dimethyl-7-oxo-9-[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazin-1-yl]carbonyl-4,6-dimethyl-7-oxo-N,N'-bis[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]-1,9-bis[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazine-1,9-dicarboxamide
 Molecular weight is 1255.42 g/mol
 Dactinomycine available : 0,5mg injection

Generic name: Dactinomycin

Brand name(s): Cosmegen, Dactinomicina, Dactinomycinum, Lyovac Cosmegen, Meractinomycin, Oncostatin K, Oxamide

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