Dactinomycinum review

Dactinomycinum is used in the treatment of various types of cancer including testicular and sarcomas. It belongs to a group of cancer-fighting medicaments that stop the growth of cancer cells in the body.


Dactinomycinum is usable under the brand names Act-D and Actinomycin D. It is commonly prescribed to children, but adults may also be prescribed this medication. Dactinomycinum is intended for the treatment of cancers of the soft tissue and bones particularly tendons and muscles, tumors in the womb, and cancer of the testicles.

Dactinomycinum is injected in a vein for over 15 minutes. Patients are usually given a medicine prior to Dactinomycinum to stop any vomiting or nausea once the medication is administered.


The dosage of Dactinomycinum will depend on the affected role's size, blood count, condition and the cancer being treated. Blood counts are taken before treatment of Dactinomycinum. In case the lab tests indicate unsafe conditions, the treatment of Dactinomycinum will be delayed.

It is usual for affected roles to take Dactinomycinum with other chemotherapy dugs.


Dactinomycinum can decrease the amount of white blood cells in the body for weeks after treatment has ended, which can increase the affected role's risk of infection. Patients should immediately inform their doctors if they experience symptoms of an infection like high fever, pain when urinating, chills, or coughs.

Dactinomycinum can lower the platelet count of the affected role for a few weeks after being used, increasing the affected role's risk of bleeding. Patients should notify their doctor if they experience unexplained bleeding including nosebleeds, tarry stools, or bleeding gums.

There is a risk that Dactinomycinum will decrease the amount of red blood cells in the body. Anemia, a decreased red blood cell count, results in difficulty in breathing, and exhaustion. Your doctor may prescribe additional medicines to prevent this condition or the affected role may need to have a blood transfusion.

Patients should not have any vaccinations while taking this medication without the prior approval of their doctor. Dactinomycinum can affect a affected role's immune system, which can alter the effectiveness of vaccinations and can lead to severe infections.


Patients may feel sick after taking Dactinomycinum so doctors usually prescribed anti-nausea medicaments to treat nausea and vomiting.

Dactinomycinum can result in rapid hair loss. However, this is a temporary side effect and the hair normally grows back after the treatment.

Patients should talk with their doctor about their complete medical history, especially if they have had liver, kidney, heart illnesses, diabetes, heart failure, gout, kidney stones, and infections. These conditions may require the dosage of Dactinomycinum to be changed accordingly.

Patients who have been treated with radiation are usually given decreased dosages of Dactinomycinum.


This medication can have an effect on the fertility of its users. It can cause birth defects, especially if the mother took Dactinomycinum during pregnancy or conception. Patients who are taking Dactinomycinum should use birth control to lessen risks of conception.

Dactinomycinum has the following structural formula:

Chemical structure of dactinomycinum

 Molecular formula of dactinomycinum is C62H86N12O16
 Chemical IUPAC Name is 8-amino-N-(2-amino-4,6-dimethyl-3-oxo-phenoxazin-1-yl)carbonyl-N'-[8-amino-4,6-dimethyl-7-oxo-9-[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazin-1-yl]carbonyl-4,6-dimethyl-7-oxo-N,N'-bis[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]-1,9-bis[[3,6,10-trimethyl-7,14-bis(1-methylethyl)-2,5,8,12,15-pentaoxo-9-oxa-3,6,13,16-tetrazabicyclo[14.3.0]nonadec-11-yl]carbamoyl]phenoxazine-1,9-dicarboxamide
 Molecular weight is 1255.42 g/mol
 Dactinomycinum available : 0,5mg injection

Generic name: Dactinomycin

Brand name(s): Cosmegen, Dactinomicina, Dactinomycine, Lyovac Cosmegen, Meractinomycin, Oncostatin K, Oxamide

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