Delavirdine review

Delavirdine is a drug used for antiretroviral treatment for infections caused by the human immunodeficiency virus (HIV) type 1. Specifically it is a non-nucleoside reverse transcriptase inhibitor.

During HIV infection, the virus reproduces through the body’s own cells. These viruses are formed within the cells and are released to infect other cells in the body. Delavirdine works by blocking the reverse transcriptase responsible for creating new copies of DNA for the newly-formed viruses – inhibiting the spread of the virus in the body. However it does not kill existent viruses, which means it will not cure HIV infections.

Unlike other HIV treatment drugs, it is readily active and does not need to be further converted in to an active form.

It is marketed by Pfizer under the brand name Rescriptor and comes in 100 or 200 mg of delavirdine mesylate tablets.

Delavirdine is prescribed for treating HIV-1 infections combined with at least 2 other antiretroviral agents as part of a coordinated antiretroviral therapy. Resistant virus strains can quickly develop when delavirdine is taken alone so it is important that delavirdine is taken as part of an antiretroviral combination therapy.

The recommended dosage for delavirdine tablets is 400 mg taken three times a day. Your doctor can provide specific instructions for delavirdine dosage as well as the dosages and other requirements of the other antiretroviral agents which will be part of the treatment.

The 100 mg tablets can be dispersed in water before consumption and may be taken with or without food. The dispersion can be prepared by dissolving 4 100 mg delavirdine tablets in 3 ounces of water, letting it stand for a few minutes, before stirring until a uniform dispersion of the drug is achieved. It should then be consumed immediately. The glass should then be rinsed in water and taken again in order to ensure that the complete dose is taken. The 200 mg tablets may not be prepared this way as they are not designed to be dispersed.

Patients with achlorhydia need to take delavirdine with an acidic beverage such as citrus or cranberry juice, but the effect of the acidic beverage on the absorption of the drug in patients with achlorhydia has yet to be seen.

More commonly, those taking delavirdine may experience rashes, headache, nausea and vomiting and diarrhea. Some may also experience difficulty sleeping, abdominal cramping and muscle pain. More serious side effects requiring medical attention may include sever rashes accompanied by blisters, fever and body pain along with red and swelling eyes, mouth sores and general swelling. Some may even develop serious kidney and liver problems. Consult your doctor immediately if you develop any of these side effects.

Anticonvulsants and other drugs may decrease concentrations of delavirdine in the blood and reduce the effect of the drug. Antacids and didanosine can also lower delavirdine levels in the blood, thus delavirdine should be taken at least an hour after taking either types of drugs.

Ketoconazole, clarithromycin, and fluoxetine on the other hand, increases concentrations of delavirdine in the bloodstream and can aggravate side effects caused by delavirdine.

Always inform your physician if you are taking any other medicine or supplements before beginning to take delavirdine.

Delavirdine has the following structural formula:

Chemical structure of delavirdine

• Molecular formula of delavirdine is C22H28N6O3S
• Chemical IUPAC Name is N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl] carbonyl-1H-indol-5-yl]methanesulfonamide
• Molecular weight is 456.562 g/mol
Delavirdine available : 100mg tablets and 200mg tablets

Brand name(s): Rescriptor

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