Desmopressin review

Desmopressin is a drug with a very specific use. It actually works by replacing, and thereby increasing, the antidiuretic hormone. This is the hormone that generates urine during sleep. This drug works by technically reduces the amount of water in the urine during sleep by re-absorbing water into the body. Desmopressin is typically used to counter bedwetting. This drug unlike its predecessors, did not affect the blood pressure of the patients taking it.

Desmopressin is also used to retain the water lost when a person suffers from Central Diabetes Insipidus, which is a disease that is characterized by uncontrollable and heavy urination. It also helps release protein like the von Willebrand factor and factor VIII in patients with coagulation disorders like mild hemophilia.

In 2007Desmopressin nasal sprays were banned in the United States after 2 children died from an imbalance of sodium levels (Hyponatremia) caused by the sprays. However, the pills were deemed safe for healthy patients, specifically patients with no diseases connected with water retention and sodium. Please be wary of unlicensed pharmacists still selling these nasal sprays. They were banned in 2007, and still have not been approved by 2008.

Because of this warning, doctors now understand that it is vital that patients stop taking Desmopressin if they have a sickness that hinders their water retention. The flu, a cough, a cold, vomiting, diarrhea, or even hot weather and thirst can be a bad combination with the drug if patients take too much Desmopressin. The fluid levels that decrease as you become sick could lead to a sodium imbalance in the body, which is very serious. Extreme cases of sodium imbalance lead to death.

It is very important that you doctor be aware of the patients medical history. If the patient has a history of blood clotting, high blood pressure, fluid or nutrient imbalance, allergives, mineral disorders, vitamin imbalance, and kidney disorders they should inform their doctors immediately. It is also important to disclose any drugs that you are currently taking to your doctor; it might clash with the Desmopressin and have bad effects on your health. Drugs like diuretics, blood medication, and laxatives usually interfere with Desmopressin. Please disclose all perscriptiona nd over the counter drugs you are taking to your doctor.

Some mild side effects that are virtually harmless still affect patients who chose to take Desmopressin. These side effects include: headache, mild nausea, stomach cramps, chills, difficulty sleeping, pain in the genitals, and mild fever. In the event of an allergic reaction the patient will most likely experience a rash, itchy feelings, seizure, vomiting, swelling and trouble breathing. If this occurs please seek medical attention.

Desmopressin is affected by alcohol, since alcohol affects a person’s ability to retain water. Please ask your doctor how much alcohol you can consume. Too much alcohol mixed with Desmopressin will have negative effects on your health. Desmopressin is marketed under the names Stimate, DDAVP, and Minirin. It is usually a small white tablet. Please take only as much as prescribed by your treating physician.

Desmopressin has the following structural formula:

Chemical structure of desmopressin

• Molecular formula of desmopressin is C46H64N14O12S2
• Chemical IUPAC Name is N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1- oxopentan-2-yl]-1- [7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[ (4-hydroxyphenyl)methyl]-6,9,12,15, 18-pentaoxo-13-(phenylmethyl)1,2-dithia-5,8,11,14,17- pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
• Molecular weight is 1069.2170 g/mol
Desmopressin available : 0.1mg tablets, 0.2mg tablets

Brand name(s): Adiuretin, Concentraid, Stimate

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