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Dexamethasone

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Dexamethasone

Dexamethasone review





Dexamethasone, which also comes under the brand names of Decadron, Decaject, Dexamethasone Intensol, Dexpak and Solurex, is a corticosteroid. It is a synthetic version of hormones which usually occur naturally in the human body; doctors prescribe it to replace those hormones when the body doesn’t make enough of it. The lack of that hormone can cause inflammation, which is relived by dexamethasone. It is also used to treat arthritis and other disorders, including skin, eye, kidney, blood, and intestinal disorders, especially colitis. It is helpful for controlling severe allergic reactions such as asthma, atopic dermatitis, allergic rhinitis, and serum sickness. It can sometimes be used to treat flare-ups of multiple sclerosis or cerebral edema. It can even be used to treat some cancers, especially as a treatment for pain.

Dexamethasone comes in tablet form and in liquid form. It is extremely important that you follow the directions exactly as they are written. If there’s anything you don’t understand, be sure to ask your doctor, nurse or pharmacist, because dosage and timetable are very precisely calibrated for this medication. Above all, do not stop taking dexamethasone abruptly or without consulting your doctor. Most steroids and other hormonally-based medications are prescribed in such a way that the dosage and frequency gradually taper off, and an abrupt stop could have serious side effects. The patient might experience loss of appetite or upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, or sudden weight loss.

Even used properly, dexamethasone may cause serious side effects. These most commonly include upset stomach, vomiting, headache, dizziness, insomnia, restlessness, depression or anxiety, acne, increased hair growth, bruising easily, and irregular periods. Other side effects that are more serious include skin rash, swelling of the face or ankles, problems seeing, colds or infections that do not seem to go away, weakness in the muscles, or black or tarry stool. If any of this second set of side effects occurs, call your doctor immediately.

It is extremely important to keep any appointments with your doctor or any appointments you have for lab work. Your doctor may want you to take certain tests in order to gauge how you are responding to the dexamthasone. If your original condition worsens, or your side effects are especially bad, this may b a sign that your dosage needs to be adjusted. One thing to be very cautious about is your exposure to other illnesses; dexamethasone lowers the human immune system and may make you more susceptible to infections or other illnesses. You must report any sign of infection, such as fever, sore throat, or muscle aches, to your doctor.

Dexamethasone can be very effective in children as well as adults. However, it should be used with great caution with pregnant women. The effects on a developing fetus are unknown, but side effects such as cleft palate have been observed in laboratory animals given a course of dexamethasone. Similarly, dexamethasone could appear in breast milk and cause growth problems for a nursing baby, so nursing mothers should make sure to speak to their doctors.

Dexamethasone has the following structural formula:

Chemical structure of dexamethasone


• Molecular formula of dexamethasone is C22H29FO5
• Chemical IUPAC Name is 9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11, 12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• Molecular weight is 392.461 g/mol
Dexamethasone available : 0.5mg/5ml elixir, 0.25mg tablets, 0.5mg tablets, 0.75mg tablets, 1mg tablets, 1.5mg tablets, 2mg tablets, 4mg tablets, 6mg tablets

Brand name(s): Adexone, Aeroseb-D, Aeroseb-Dex, Anaflogistico, Aphtasolon, Aphthasolone, Auxiron, Azium, Bisu Ds, Calonat, Corson, Corsone, Cortisumman, Decacort, Decacortin, Decaderm, Decadron, Decadron-La, Decagel, Decalix, Decasone, Decaspray, Dectancyl, Dekacort, Deltafluorene, Dergramin, Deronil, Desadrene, Desametasone, Desamethasone, Desameton, Deseronil, DEX, Dex-Ide, Dexa, Dexa Mamallet, Dexacen-4, Dexacidin, Dexacort, Dexacortal, Dexacortin, Dexadeltone, Dexafarma, Dexair, Dexalona, Dexaltin, Dexametasona, Dexameth, Dexamethasonum, Dexamethazone, Dexamonozon, Dexapolcort, Dexapos, Dexaprol, Dexason, Dexasone, Dexinolon, Dexinoral, Dexone, Dexonium, Dextelan, Dezone, Dinormon, DXM, Dxms, Fluormethylprednisolone, Fluormone, Fluorocort, Fortecortin, Gammacorten, Hexadecadrol, Hexadrol, Lokalison F, Loverine, Luxazone, Maxidex, Maxitrol, Mediamethasone, Mexidex, Millicorten, Mymethasone, Ocu-Trol, Oradexon, Policort, Prednisolon F, Prednisolone F, Spoloven, Superprednol, Tobradex, Turbinaire, Visumetazone

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