Dexrazoxane review

Dexrazoxane is a cardioprotective agent used in preventing cardiovascular condition during chemotherapy. A substance derived from EDTA, dexrazoxane chelates iron and is believed to interfere with harmful substances inside cells which may cause heart disease after using anthracyclines such as doxorubicin. However, exactly how dexrazoxane works in protecting the heart is not fully understood. It is available as Zinecard in the United States and Canada, and Cardioxane in the EU. Zinecard is available in 250 mg and 500 mg vials for injection.

Dexrazoxane is administered to prevent the incidence and reduce the severity of heart conditions which may occur during chemotherapy using anthracyclines, such as those in the treatment of women suffering from metastatic breast cancer.

A dexrazoxane drug marketed under brand name Totect or Savene has also been approved for use as a treatment of extravasation caused by anthracycline chemotherapy. Extravasation occurs during chemotherapies when anthracycline leaks out of the blood vessels and seeps to the skin.

The dose of dexrazoxane is dependent on the body surface area of the patient as well as the doxorubicin dose currently being taken. The dose is usually measured in a 10:1 ratio with respect to the doxorubicin dose. Once the proper dose has been measured, the drug can be administered directly into the vein via an IV push or through a quick infusion from an IV infusion bag. 30 minutes after the administration of dexrazoxane the IV injection of doxorubicin can now be given.

Dexrazoxane, is stable for about 6 hours after reconstitution if placed in an empty infusion bag at controlled room temperature ranging from 15 to 30C (59 to 86F), or placed in refrigeration at 2 to 8C (36 to 46F). It may also be diluted using a 0.9% sodium chloride injection, USP or using a 5.0% dextrose injection, USP. Dilute the medication to a concentration between 1.3 to 5.0 mg/mL and store them in empty IV infusion bags. Do not reuse leftover solutions.

One of the usual side effects experienced those undergoing dexrazoxane treatment is pain or swelling at the injection site. All blood counts can also be observed to be lower when taking dexrazoxane with chemotherapy compared to undergoing chemotherapy alone. Recovery periods for the blood counts do remain similar for both cases.

Other common side effects experienced include diarrhea, general discomfort, fever, loss of appetite or nausea. More serious side effects involve hair loss, vomiting, swelling of the throat and tongue, as well as severe allergic reactions that require immediate medical attention.

Dexrazoxane should only be used in conjunction with anthracycline chemotherapy such as doxorubicin.

Certain chemotherapy may cause sterility in both men and women so consult your doctor if you plan on having children. However, it is not yet been shown that dexrazoxane itself can cause sterility. If you believe that you might be pregnant then inform your doctor about your condition before being administered dexrazoxane.

You may also experience greater susceptibility to infection during treatment so consult with your doctor before get live virus vaccines to avoid complications.

Dexrazoxane has the following structural formula:

Chemical structure of dexrazoxane

• Molecular formula of dexrazoxane is C11H16N4O4
• Chemical IUPAC Name is 4-[1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
• Molecular weight is 268.269 g/mol
Dexrazoxane available : 250mg injection and 500mg injection

Brand name(s): Cardioxane, Desrazoxane, Dexrazoxano, Dexrazoxanum, Dextrorazoxane, Dyzoxane, Eucardion, Razoxana, Razoxane, Razoxanum, Razoxin, Tepirone, Troxozone, Zinecard

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