Dexrazoxano review

Dexrazoxano is a cardioprotective agent used to prevent cardiovascular conditions during chemotherapy. A substance derived from EDTA, Dexrazoxano chelates iron, is believed to interfere with substances inside cells, which may cause heart illness after using anthracyclines such as doxorubicin. Exactly how Dexrazoxano works in protecting the heart is not fully understood. This medicament is available as Zinecard in the United States and Canada, and Cardiozane in the EU and is available in 250 mg and 500 mg vials for injection.

Dexrazoxano is taken to prevent and reduce the severity of heart conditions which may occur during chemotherapy using anthracyclines, such as those used in the treatment of women suffering from metastatic breast cancer.

Dexrazoxano marketed under brand name Totect or Savene has also been approved for use as a treatment of extravasation caused by anthracycline chemotherapy. Extravasation occurs when anthracycline leaks out of the blood vessels and seeps to the skin.

The dosage of Dexrazoxano depends on the organic structure surface area of the affected role as well as the doxorubicin dosage being taken. It is usually measured in a 10:1 ratio with respect to the doxorubicin dosage. Once the proper dosage has been measured, the medicament can be administered directly into the vein via an IV push or through a quick infusion from an IV infusion bag. 30 minutes after the administration of Dexrazoxano the IV injection of doxorubicin can be given.

Dexrazoxano, is stable for about 6 hours after reconstitution if placed in an empty infusion bag at controlled room temperature ranging from 15 to 30C (59 to 86F), or placed in refrigeration at 2 to 8C (36 to 46F). It may also be diluted using a 0.9% sodium chloride injection, USP or using a 5.0% dextrose injection, USP. Dilute the medicament to a concentration between 1.3 to 5.0 mg/mL and store in empty IV infusion bags. Do not use leftover solutions.

One of the usual side effects experienced by those undergoing Dexrazoxano treatment is pain or swelling at the injection site. All blood counts can also be lower when taking Dexrazoxano with chemotherapy compared to undergoing chemotherapy alone. Recovery periods for the blood counts do remain similar for both cases.

Other common side effects experienced include diarrhea, general discomfort, fever, loss of appetite and wamble. More serious side effects involve baldness, vomiting, swelling of the throat and tongue, and severe allergic reactions that require immediate medical attention.

Dexrazoxano should only be used in conjunction with anthracycline chemotherapy such as doxorubicin.

Certain chemotherapy may cause sterility in both men and women so consult your doctor if you plan on having children. However, it has not yet been shown that Dexrazoxano itself can cause sterility. If you believe that you might be pregnant, inform your doctor about your condition before being given Dexrazoxano.

You may also experience greater susceptibility to infection during treatment so consult with your doctor before getting live virus vaccines to avoid complications.

Dexrazoxano has the following structural formula:

Chemical structure of Dexrazoxano

• Molecular formula of dexrazoxano is C11H16N4O4
• Chemical IUPAC Name is 4-[1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
• Molecular weight is 268.269 g/mol
Dexrazoxano available : 250mg injection and 500mg injection

Generic name: Dexrazoxane

Brand name(s): Cardioxane, Desrazoxane, Dexrazoxanum, Dextrorazoxane, Dyzoxane, Eucardion, Razoxana, Razoxane, Razoxanum, Razoxin, Tepirone, Troxozone, Zinecard

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