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Dexrazoxanum

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Dexrazoxanum

Dexrazoxanum review





Dexrazoxanum is a cardioprotective agent used to prevent cardiovascular conditions during chemotherapy. A substance derived from EDTA, Dexrazoxanum chelates iron, is trustd to interfere with substances inside cells, which may cause heart illness after using anthracyclines such as doxorubicin. Exactly how Dexrazoxanum works in protecting the heart is not fully understood. This medication is available as Zinecard in the United States and Canada, and Cardiozane in the EU and is available in 250 mg and 500 mg vials for injection.

Dexrazoxanum is taken to prevent and reduce the severity of heart conditions which may occur during chemotherapy using anthracyclines, such as those used in the interference of women suffering from metastatic breast cancer.

Dexrazoxanum marketed under brand name Totect or Savene has also been approved for use as a interference of extravasation caused by anthracycline chemotherapy. Extravasation occurs when anthracycline leaks out of the blood vessels and seeps to the skin.

The dosage of Dexrazoxanum depends on the organic structure surface area of the patient as well as the doxorubicin dosage being taken. It is usually measured in a 10:1 ratio with respect to the doxorubicin dosage. Once the proper dosage has been determined, the medication can be administered directly into the vein via an IV push or through a quick infusion from an IV infusion bag. 30 minutes after taking Dexrazoxanum, the IV injection of doxorubicin can be given.

Dexrazoxanum is stable for about 6 hours after reconstitution when placed in an empty infusion bag at controlled room temperature ranging from 15 to 30C (59 to 86F), or placed in refrigeration at 2 to 8C (36 to 46F). It may be diluted using a 0.9% sodium chloride injection, USP or using a 5.0% dextrose injection, USP. Dilute the medication to a concentration between 1.3 to 5.0 mg/mL and store in empty IV infusion bags. Do not use leftover solutions.

One of the side effects experienced by those undergoing Dexrazoxanum interference is pain or swelling at the injection site. Blood counts can also be lower when taking Dexrazoxanum with chemotherapy compared to undergoing chemotherapy alone. Recovery periods for the blood counts remain similar for both cases.

Other common side effects include diarrhoea, general discomfort, fever, loss of appetite and wamble. More serious side effects involve hair loss, vomiting, swelling of the throat and tongue, and severe allergic reactions that require immediate medical attention.

Dexrazoxanum should only be used with anthracycline chemotherapy such as doxorubicin.

Chemotherapy may cause sterility in both men and women so consult your doctor if you plan on having children. However, it has not yet been shown that Dexrazoxanum itself can cause sterility. If you trust that you might be pregnant, inform your doctor about your condition before being given Dexrazoxanum.

You may also experience greater susceptibility to infection during interference so consult with your doctor before getting live virus vaccines to avoid complications.



Dexrazoxanum has the following structural formula:

Chemical structure of Dexrazoxanum


• Molecular formula of Dexrazoxanum is C11H16N4O4
• Chemical IUPAC Name is 4-[1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
• Molecular weight is 268.269 g/mol
Dexrazoxanum available : 250mg injection and 500mg injection

Generic name: Dexrazoxane

Brand name(s): Cardioxane, Desrazoxane, Dexrazoxano, Dextrorazoxane, Dyzoxane, Eucardion, Razoxana, Razoxane, Razoxanum, Razoxin, Tepirone, Troxozone, Zinecard

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