Diaphenylsulfone review

Diaphenylsulfone is for treating leprosy and dermatitis herpetiformis and as an anti-infective medication, can be used for other purposes.


Diaphenylsulfone has been known to cause serious, even fatal skin reactions, though rare. It is important that patients be educated on the potentially severe skin reactions before they begin taking Diaphenylsulfone. This medication has been associated with serious blood and liver conditions, though the cases are rare. Patients need to seek immediate emergency medical attention should they experience sore throat, fever, pale skin, bruising, pinpoint red spots on the skin, or jaundice. These might be signs of a life threatening condition.

Diaphenylsulfone should not be prescribed without knowing the patient’s complete medical history. Patients with a history including liver disease, glucose 6 phosphate dehydrogenase, or methemoglobin reductase deficiency may require special monitoring while taking Diaphenylsulfone. These patients may not be able to take this medication at all, depending on the condition and the severity of the condition.


Diaphenylsulfone is rated pregnancy risk category C by the FDA and has not been determined if this medication will cause harm or birth defects in an unborn fetus. This medication will pass through breast milk and cause harm to a nursing baby. Pregnant and nursing patients should not take Diaphenylsulfone.


Take a missed dose as soon as remembered unless it is almost time for the next dose, in which case the missed dose should be skipped. Taking two doses too closely together or taking a double dose to make up for a missed one can cause an overdose. An overdose can lead to serious consequences. If you experience symptoms of an overdose, seek emergency medical attention immediately. Symptoms include blue skin tone, excitability, nausea, vomiting, seizures, and muscle weakness.


Patients experiencing serious side effects or an allergic reaction are advised to seek immediate emergency medical attention. Allergic reactions, sometimes life threatening, include difficulty breathing, hives, and facial swelling. Serious side effects include blue skin tone, numbness, tingling, muscle weakness, difficulty breathing, abdominal pain, dark urine, pale stools, and unusual fatigue.

Other side effects don’t require emergency medical attention but need to be reported to your healthcare professional. These include insomnia, headache, blurry vision, nausea, vomiting, ringing in the ears, and increased sensitivity to light.


Medications that affect the blood, liver, and skin may interact negatively with Diaphenylsulfone to the point of causing serious medical conditions. It is best to take Diaphenylsulfone by itself to avoid the multitude of medications that can cause serious interactions. When other medications are prescribed in conjunction with Diaphenylsulfone, blood tests to monitor liver and blood functions are necessary to ensure that the body is maintaining an appropriate level of health.

Diaphenylsulfone has the following structural formula:

Chemical structure of diaphenylsulfone

 Molecular formula of diaphenylsulfone is C12H12N2O2S
 Chemical IUPAC Name is 4-(4-aminophenyl)sulfonylaniline
 Molecular weight is 248.302 g/mol
 Diaphenylsulfone available : 25mg tablets, 100mg tablets

Generic name: Dapsone

Brand name(s): Acedapsone, Araldite Ht, Avlosulfon, Avlosulfone, Avlosulphone, Croysulfone, Croysulphone, Dapson, Dapsonum, Diaphenylsulfon, Diaphenylsulphon, Diaphenylsulphone, Dimitone, Diphenasone, Diphone, Disulone, Dubronax, Dumitone, Eporal, Maloprim, Normet, Recolip, Sulfadione, Sulfona, Sulfone Ucb, Sulfonyldianiline, Sulphadione, Sulphonyldianiline, Sumicure S, Tarimyl, Udolac

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