Diazepam review

Diazepam, more popularly known under the brand name Valium, is a versatile drug possessing various effects which make it quite valuable it has been used as anticonvulsant, sedative, hypnotic, skeletal muscle relaxant and many other roles. Diazepam is usually prescribed to treat anxiety, seizures, insomnia, muscle spasms, alcohol withdrawal and withdrawals syndromes (such as benzodiazepine). It may also be used in certain procedures such as endoscopies in order to relieve tension and anxiety or to induce amnesia in certain surgical operations.

It is available in a wide variety of different forms such as 2 mg, 5 mg, and 10 mg tablets, injection, solutions and suppositories for renal administration, and even inhalers.

It has been listed as one of the World Health Organization’s “Essential Drugs List” for the minimum needs of each basic health care service and has been used to treat a wide variety of conditions – earning its reputation as one of the most prescribed medication in the whole world.

Diazepam is indicated to treat a wide of different variety of conditions and situations. It is prescribed to treat anxiety and panic attacks, for the short-term relief from insomnia and for painful muscle conditions and symptoms needing muscle relaxants. It has even been indicated for treating hallucinogen overdose and other CNS disturbances and for treating spine-injury related conditions.

Dosage for diazepam varies differently for each situation and patient, taking into consideration the difference in age, medical history and condition. Your physician will be able to give more precise and specific instructions for taking diazepam.

Typically, the usual dosages for healthy adults can range from 2 mg to 10 mg each dose taken, with the dose taken 2 to 4 times daily. Dosages for elderly people and those suffering from liver conditions are often smaller at the beginning and will be increased and adjusted accordingly.

Diazepam may cause a host of side effects that are common to other drugs of the same type. These side effects include drowsiness, reduction of REM sleep, impaired coordination and motor skills, dizziness and nausea, depression, balance problems, difficulty learning and even irregular heartbeat and anterograde amnesia possible in higher doses.

There are some rare counter-intuitive side effects experienced such as anxiety, irritability, insomnia, and in some cases increased tendency for rage and violence.

Many drugs will enhance and increase the effects of diazepam when taken together – these include barbiturates, narcotics, and anti depressants. It also increases the effect of alcohol in the central nervous system, lowering blood pressure and increasing the depressive effects. Oral contraceptives may also inhibit the elimination of diazepam form the body. Tobacco use may also facilitate the elimination of diazepam and decrease its effectiveness.

Diazepam should be avoided when pregnant, particularly in the third trimester where significant risks exist for the infant to develop withdrawal symptoms from diazepam as well as develop impaired responses and hypotonia.

Diazepam also faces potential for substance abuse, and can lead to withdrawal symptoms similar to barbiturate or alcohol dependence. Thus it is recommended that diazepam to be used only for short term treatments.

Diazepam has the following structural formula:

Chemical structure of diazepam

• Molecular formula of diazepam is C16H13ClN2O
• Chemical IUPAC Name is 9-chloro-2-methyl-6-phenyl-2,5-diazabicyclo[5.4.0] undeca-5,8,10,12-tetraen-3-one
• Molecular weight is 284.74 g/mol
Diazepam available : 2mg tablets, 5mg tablets and 10mg tablets

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