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Digoxin

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Digoxin

Digoxin review





Digoxin is primarily a heart medication. It is used to treat heart conditions like heart failure, atrial fluttering, and atrial fibrillation. Interestingly enough, it is a drug that has been purified and modified from the parts of the foxglove plant. However medieval its origin; its use is almost futuristic. Digoxin is actually used to control the electrical impulses of the heart to make the heart rate more controlled and stable. It slows down the electricity in the AV node (the area of tissue between the atria and ventricles of the heart) and the heart pumps slower and is filled with more blood.

This drug is particularly sensitive to other drugs, since its toxicity is very delicate other chemicals in the body sometimes react badly with it. Patients with low potassium levels are at greater risk for toxicity and a bad reaction to the drug. Some drugs that researchers say react badly with Digoxin are: antimalarial medication, other heart medication, Hydroxychloroquine, verapamil, erythromycin, amiodarone, and epinephrine which is commonly used in anesthetics. To be safer, it is better to reveal all the drugs, over the counter or other prescription drugs so that your doctor can adjust the dose if he needs to. As previously stated, Digoxin is a delicate drug. It might react badly with many different things.

It is important to disclose your entire medical history before taking any new medication. Something, a previous illness or a vitamin you are regularly taking, might interfere with the Digoxin treatment. It is important to tell your doctor all the previous operations you have had, especially on the liver, kidney and heart. It’s also important that you reveal to him all the illnesses you’ve previously had. Kidney disesase and thyroid disases are especially dangerous because they make your body more sensitive to digoxin.

This drug is classified as a FDA pregnancy category C. This means that they researchers don’t know if the drug may be harmful to pregnant women and their fetuses. To be safe, please inform your doctor if you are pregnant or if you become pregnant during the course of the Digoxin treatment. This also means that they do not know if the drug is passed on through mother’s milk. It might be better if nursing mothers stop breastfeeding while on the drug treatment.

Sometimes drugs can cause discomfort in the patient because it changes the body rhythm, or the body’s chemicals to make it better. Some of the common side effects from Digoxin are: nausea, vomiting, enlarged breasts in males, stomach problems, confusion, depression, and problems sleeping. These are mostly negligible side effects. However, there are also some serious side effects that might happen these include: amnesia, delirium, heart failure, heart blockage. If any of these serious side effects occur, do not hesitate to go to a doctor immediately. If you are allergic to Digoxin it will manifest in rashes, hives, fainting, extreme headaches, varied and irregular heartbeats, abnormal vision, hallucinations or psychotic behavior. If any of these symptoms manifest please see a doctor at once. Dioxin is usually given once daily in 200-250 mg doses. It can also be injected in .25 mgs doses. It is marketed under the names Lanoxin, Digitek, and Lanoxicaps. It is also known as Digitalis. Make sure that you follow the doctor’s prescription as you take this drug treatment. Take only what he tells you to, no more and no less.

Digoxin has the following structural formula:

Chemical structure of digoxin


• Molecular formula of digoxin is C41H64O14
• Chemical IUPAC Name is 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5- [(2S,4S,5R,6R)-4,5- dihydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl- oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy- 12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17- tetradecahydrocyclopenta[a] phenanthren-17-yl]-5H-furan-2-one
• Molecular weight is 780.938 g/mol
Digoxin available : 0.125mg tablets, 0.25mg tablets

Brand name(s): Cardoxin, Cogoxin, Cordioxil, Davoxin, Digacin, Digitalis Glycoside, Digitekt, Dilanacin, Dixina, Dokim, Dynamos, Eudigox, Lanacordin, Lanacrist, Lanicor, Lanoxicaps, Lanoxin, Lenoxicaps, Lenoxin, Longdigox, Neo-Lanicor, Neodioxanin, Rougoxin, Stillacor, Vanoxin

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