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Dipyrone


Dipyrone

Dipyrone review



buy Dipyrone Buy Dipyrone
Dipyrone is a type of nonsteroidal anti-inflammatory drug. It is known as metamizole. Its mechanism is found to be similar to other NSAIDs that inhibit the production of prostaglandin.

Dipyrone (metamizole) is a nonsteroidal anti-inflammatory drug. The mechanism of action of dipyrone is thought to be similar to that of other NSAIDs: inhibition of the production of prostaglandins. It is commonly used in the horse as an antipyretic, analgesic, and anti-inflammatory.

Metamizole was first produced by a German company Hoechst AG during the 1920’s, and started mass production in 1922. It remained available to the market until the 1970’s until it was discovered to be a risk of causing agranucolytosis. Medical authorities have banned the sale of the drug either totally or were made by prescription, while some still maintained it as over the counter.

Metamizole was historically used as a powerful painkiller and fever reducer. It is commonly known as Dipyrone, Analgin, Novalgin and Melubrin. The drug is available in two formulations – tablets and ampoules for injection. Tablets are used for pain treatment of various origins and intensity: toothache, myositis, neuralgia, headache, and fever. Injections of this drug are used to treat acute and severe pain usually post trauma or operations.

Dipyrone is produced as both ampoules and tablets. The ampoules may be administered intramuscularly. A single dose is formulated at 8 to 165 mg/kg of body weight. Administration is given depending on body weight: 250 mg for people weighing 16 – 31 kg; 500 mg for 32 – 46 kg; 500 – 750 mg of Dipyrone for 47 – 62 kg and for those weighing over 63 kg, 750 – 1000 mg should be used.

The tablet formulation is administered depending on the intensity of the pain. Common dosage is 250 – 500 mg (1 or 2 tablets) given twice or thrice daily. Maximum dosage is 3 tablets over a 24 hour period.

One of the most common side effects when dipyrone is administered is skin reaction on the site of injection. They usually are treated with hot compress and NSAIDs. The most severely reported side effect dipyrone may bring would be bone marrow-related diseases such as leucopenia and agranulocytosis. This has caused the restriction of the drug.

Usage of dipyrone with NSAID may increase its analgesic and antipyretic levels. The pain killing effects of dipyrone may be potentiated by the use of antidepressants, contraceptive agents, and alcohol, decreasing the activity of coumarin anticoagulants and the plasma levels of cyclosporine. Severe hypothermia may develop if dipyrone is administered concurrently with chlorpromazine. Dipyrone may however be used with buscolysin, atropine and codein.

Extreme caution is used when administering dipyrone to patients with a history of hypersensitivity to food and drugs – specifically with NSAIDs. Patients with bronchial asthma and other pulmonary infections are also monitored closely. Dipyrone should not be given to patients with hypotension and unstable levels of blood pressure. Activities that require mental focus such as machine operation and driving is to be avoided when taking dipyrone as it unfavorably affects active attention.

Dipyrone has the following structural formula:

Chemical structure of dipyrone


• Molecular formula of dipyrone is C13H16N3NaO4S
• Chemical IUPAC Name is sodium [(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonate
• Molecular weight is 333.3386 g/mol
Dipyrone available : 500mg tablets

Brand name(s): Alginodia, Algocalmin, Algopyrine, Analgin, Barone, Bonpyrin, Conmel, Di-podil, Dimethone, Diprofarn, Farmolisina, Feverall, Fevonil, Gifaril, Keypyrone, Metamizol, Metapyrin, Methylmelubrin, Metilon, Narone, Neo-melubrine, Neomelurbrin, Nevralgina, Novaldin, Novalgetol, Novalgin, Noveltex, Optalgin, Paralgin, Pharmalgine, Pyralgin, Pyretin, Pyrojec, Sulpin, Sulpyrin, Sulpyrine, Sulpyrinum

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