Divalproex Sodium also known as Valproate Semisodium is an anti-seizure drug. It is used to control manic episodes of patients with bipolar disorder. In the United States, it is also used to treat epilepsy, neuropathy, and migraine. Divalproex Sodium is widely available in the United States and the United Kingdom under the brand names Depacon, Depakene, and Depakote among others.
Divalproex Sodium is a complex prescription medicine that needs to be handled carefully. When used properly it is proven to be effective in controlling manic-depressive episodes, epileptic seizures, and even in preventing adults from contracting migraine. It works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that prevents the nerve cells from getting activated. A sufficient level of GABA, which is increased with a Divalproex Sodium intake, makes it possible for the occurrence of seizures to be decreased.
Divalproex Sodium is taken orally by mouth. It comes in tablet, capsule, and syrup forms. Divalproex Sodium is available in 125mg, 250mg, and 500mg tablets; 125mg immediate-acting and 500mg extended-release capsules; and 250mg suspension per 5ml syrup. Dosage requirement depends on a lot of factors. For one, you can be judged according to your weight and according to your level of affliction. Manic-depressive patients are usually advised to take 750mg of Divalproex Sodium per day. The dosage is adjusted depending on the patient’s progress with the drug. If it is used to prevent migraine, 250mg of Divalproex Sodium is used twice a day. Make sure that you have consulted a qualified doctor before taking the drug. Several precautions must be taken to ensure your safety.
Your medical history of ailments apart from what Divalproex Sodium is meant to treat must be discussed. A greater risk of creating damage to the liver has been found in patients who have known liver disorder, kidney ailments, and blood disease. Divalproex Sodium is also found unsafe for patients under the age of two and for those who have existing brain disorders such as Alzheimer’s, Parkinson’s, Multiple Sclerosis, Mental Retardation, and many others. You also need to disclose both prescription and non-prescription drugs that you are using including your vitamins. Drugs may counteract the effect of Divalproex Sodium. Blood platelet count and coagulation parameters must also be verified before using the drug. Divalproex Sodium may cause a drop on platelet count and may also interfere with blood clotting so it is safe to undergo blood tests first before using it. Pregnant women must also take extra precaution when taking Divalproex Sodium and any drug for that matter. Divalproex Sodium, for one, is associated with birth defects. The drug is also excreted in breast milk, which means that your newborn could absorb it through breast feeding.
Side effects of Divalproex Sodium include mild stomach pains, diarrhea, hair loss, and decreased appetite among others. If you feel that your symptoms are too difficult to bear due to its severity, talk to your doctor about possible dosage adjustments. Also, remember that mild episodes of such conditions occur only until your body is able to adjust to the medicine. It should not be there for as long as you are using the medicine, especially if you are prescribed to take Divalproex Sodium long-term. Any concern about your condition must be brought to your doctor’s attention immediately.
Divalproex sodium has the following structural formula:
• Molecular formula of divalproex sodium is C16H31NaO
• Chemical IUPAC Name is sodium; 2-propylpentanoate; 2-propylpentanoic acid
• Molecular weight is 310.405 g/mol
• Divalproex sodium available : 125mg tablets, 250mg tablets, 300mg tablets, 500mg tablets
Brand name(s): Convulex, Depakene, Depakine, Depakote, Depakote CP, Depakote ER, Dipropylacetic acid, Epilim, Epival, Ergenyl, Mylproin, Propylvaleric acid
Review published on: 23 April 2008
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