Dofetilide review

Dofetilide is a drug considered as a class III antiarryhthmic agent. Antiarrhythmic agents are drugs that are supposed to control or suppress fast rhythms of the heart (cardiac arrhythmia). Examples of such conditions would be atrial fibrillation and flutter, ventricular fibrillation and tachycardia. Although the use of such drugs is still in use today, the question of suppressing arrhythmias to prolong life is still left unanswered.

The drug dofetilide is a powder with a white to off-white color. It is slightly water soluble, and soluble to propan2-ol. It is also soluble in a solution of 0.1M aqueous sodium hydroxide, acetone and 0.1M of hydrochloric acid.

Dofetilide is marketed as Tikosyn, and is used for the maintenance of rhythmic heartbeat (sinus rhythm) in patients prone to developing atrial fibrillation and flutter. It is generally used to treat irregular heartbeats by improving the heart rhythm as it relaxes an overactive heart.

Dofetilide or Tikosyn capsules are composed of the following inactive contents: microcrystalline cellulose, colloidal silicon dioxide, cornstarch, and magnesium stearate. It is taken orally, with three prescribed dosage strengths: 125 mcg (0.125mg), 250 mcg (0.25mg) and 500mcg (0.5mg).

Dofetilide should be taken orally. Once dofetilide is taken, hospital monitoring is essential in order to prevent development of side effects. The dosage to be prescribed to the patient varies on the medical condition.

Nausea or headache is one of the most commonly reported side effects of dofetilide. However, more serious side effects such as fainting, dizziness and even irregular heartbeat may occur. Report these side effects to the doctor immediately once they are experienced to prevent further complications. Possible side effects resulting to mineral imbalance may occur as well such as muscle weakness or cramps, diarrhea, thirst or sweating excessively, appetite loss and vomiting.

The most serious side effect reported for dofetilide therapy is torsades de pointes. This is however, dose-related, as a higher incidence of torsades de pointes associated with higher doses of dofetilide administration.

It is highly recommended that prior to taking dofetilide, patients must be administered in a hospital for at least three days in order to properly monitor heart functions, as well as other internal functions such as liver and renal activity. Detailed medical history such as hypersensitivity or allergic reactions to dofetilide and other drugs must be reported to the doctor prior to dofetilide administration. The use of dofetilide in the elderly is given caution as it may cause a decrease in kidney function. Pregnant and breast feeding women, and women in general should also be cautioned on the use of dofetilide as they are reported to be more prone to the serious side effects. The drug may cause harm to the fetus, and the drug is reported to be passed on to the breast milk.

Dofetilide should not be used with the drug hydrochlorothiazide, or any drug that may interfere with kidney action. This may include cation transport inhibitors such as prochlorperazine, crimetidin, ketoconazole, megestrol and trimethoprim containing drugs. Antipsychotics, protease inhibitors, and anti-depressants should also be avoided when taking dofetilide. Generally, drugs that affect the central nervous system, the kidneys and the heart must be avoided when taking in difotelide. Clas I or III antiarrhythmic agents such as amiodarone should be stopped for a few days prior to starting dofetilide.

• Molecular formula of dofetilide is C19H27N3O5S2
• Chemical IUPAC Name is N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methyl- amino]ethyl]phenyl]methanesulfonamide
• Molecular weight is 441.567 g/mol
Dofetilide available : 125mcg tablets, 250mcg tablets and 500mcg tablets

Brand name(s): Dofetilida, Dofetilidum, Tikosyn

  Your Dofetilide review