is a drug that mimics the effects of the naturally occurring hormone
. Lack of progesterone is usually thought to be the cause of a variety of menstrual disorders. As such, Dyrdrogesterone is used as treatment.
Initially introduced in 1961, Dydrogesterone has received approval in more than 100 countries. Also, it is estimated that over 28 million as used it as treatement.
It is sold under the brand name, Duphaston
Dydrogesterone is a powerful drug that is activated through oral consumption. It is effective for a multitude of gynecological conditions. As a synthetic hormone, Dydrogesterone has a similar molecular structure to natural progesterone, however it is far more potent with lower doses delivering the same results as higher doses of natural progesterone. Moreover, Dydrogesterone does not exhibit other negative hormonal effects that are usually present in synthetic versions of progesterone.
Dydrogesterone functions by acting on the neuro-endocrine control of ovarian function. Also, it can affect the functions related to the endometrium
. Because of the effects it can produce, Dydrogesterone is generally recommended for all cases of progesterone deficiency. Generally, Dydrogesterone is effective in alleviating symptoms related to Pre-Menstrual syndrome. More over, it can reduce occurrences of extremely heavy bleeding during the menstrual period.
Dydrogesterone has been proven effective for the treatment of abdominal pain and bleeding related to pregnancy. It can also alleviate pain experienced during menstruation. It can also aid in regulating the menstrual cycle
It also helpful in the treatment of endometriosis
, a condition wherein there is excess growth in the tissues in the endometrial lining. In fact, Dydrogesterone is a favored treatment since it does not affect ovulation. This means the patient can get pregnant while undergoing treatment and this will not have any negative effect on the child. Dydrogesterone also prevents the development of endometrial hyperplasia.
For women who are under endrogen hormone therapy, Dydrogesterone can make sure that the menstrual cycle will continue normally. It can also counteract any negative effect on the endometrium that may be caused by the increased levels of endrogen.
Dydrogesterone has also been found as an effective aid in the treatment of female infertility. In fact, compared to women who are not taking Dydrogesterone, women taking it can increase their chance of pregnancy by almost 50%. This happens because Dydrogesterone alleviates luteal insufficiency. This way, there is an increased chance of a successful ovum implantation in the uterus
When used for hormone therapy, Dydrogesterone can prevent hot flushes, especially in menopausal women. It can also prevent bone
Moreover, it is beneficial to take Dydrogesterone as a progesterone replacement since unlike other synthetic progesterone, Dydrogesterone is not linked to testosterone. As such, it will not cause acne
, voice changes and it has no adverse affect female fertility.
As mentioned this drug can be taken orally. The frequency and duration of treatment must be determined by a qualified health professional.
As for side effects, some patients report experiencing nausea
. Some also experience light spotting or bleeding in between menstrual period.
Dydrogesterone has the following structural formula:
• Molecular formula of dydrogesterone is C21H28O2
• Chemical IUPAC Name is (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15, 16,17-decahydrocyclopenta[a]phenanthren-3-one
• Molecular weight is 312.4458 g/mol
• Dydrogesterone available : 10mg pills