Econazole review

Econazole is a member of antifungal drugs used to treat the existence of fungi and other similar microorganisms in the body s skin. It is a topical solution administered on an affected area and prevents the metabolic and reproductive process, thereby killing it. It is also considered a prescription drug and should only be bought and used upon a proper prescription and application direction to prevent any unwanted or untoward effects.

Some of the most common forms of fungal infestation are in the form of jock's itching, ringworms, athlete's foot, yeast infection, and tinea versicolor or the discoloration of the skin brought about by the proliferation of the fungus on the body skin surface.

The main component responsible for the primary delivery of therapeutic effect is econazole nitrate. It has a rather slow absorption rate for the system to integrate as studies have shown that less than 1% of the total applied dose to be found in the patient's urine and feces. This would show a safe index for topical applications.

Econazole is created to be effective against the following strains of fungi: Candida albicans, Microsporum spp., Trichophyton spp., and Malassezia furfur. It also has a potential antifungal property against other Candida spp. variants.

Patients who have been determined and diagnosed with skin fungal infection are subjected for econazole treatment.

Anyone who has no known hyper reactivity or sensitivity to the drug may be prescribed and administered with the said drug. It is purely topical and should be, like any usual preparation of its kind, should be avoided on mucous membranes such as the nostrils, buccal cavity, ophthalmic region, and other similar internal pockets.

Application and dosage is not strictly indicated, but a sufficient amount of ointment or cream should be applied over the affected skin area twice per day. It is suggested that the application be done once after taking the morning bath, and another before sleeping, but not without taking an evening bath as well.

Expected treatment duration for the drug regimen would be within two weeks, with greater chances upon improved personal hygiene practices. Avoiding having the skin subjected to too much moisture may also help improve the destruction of fungi during medication.

Serious side effects are not to be expected from econazole administration, though there are times when minor or mild reactions occur. Nevertheless, it is highly recommended to desist from using the econazole cream and seek a doctor's advice once any side effect becomes evident. Some of the most common side effects are blistering, redness, swelling, peeling, dryness, or any other form of irritation of the skin.

As a general rule on drug administration precaution, it is highly suggested to be observant for any side effect that may occur to prevent any further unwanted outcomes. The drug is strictly for external use only and should not be ingested or mixed with any internal preparations whatsoever.

It should also be understood that even with the topical preparation, the application of the cream should only be openly used during the first trimester of pregnancy, and needing the use for econazole beyond the first trimester should be strictly used with precaution and only with a clear need as addressed by the physician. On a similar note, special precaution should be given to lactating mothers as there are no solid evidences that the drug would be excreted in the milk from the lactating breasts.

Econazole has the following structural formula:

Chemical structure of econazole

• Molecular formula of econazole is C18H15Cl3N2O
• Chemical IUPAC Name is 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole
• Molecular weight is 381.683 g/mol

Brand name(s): Ecostatin, Gyno-Pevaryl, Ifenec, Palavale, Pevaryl, Spectazole

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