Endantadine review

Endantadine, approved by the FDA in 1996, is a manmade anti-viral medication that hampers the duplication of a virus within cells. Currently, it is not known how it works in treating Parkinson's disease, just that it does work. The effects it has on the illness may be connected to the medicine’s ability to amplify the effects of dopamine, a neurotransmitter in the brain whose function is usually lacking in patients with Parkinsons disease.

Anyone suffering from Parkinson's disease or who wants to prevent the spread of a viral infection (particularly influenza) would be a candidate for this medicine.

To prevent viral infection, the medication should be given prior to exposure to the virus just as with a vaccine. Though not a practical treatment for most viral infections, it has been used to prevent Influenza A during flu season. Even when given a day or two after the onset of flu symptoms, it has been effective in decreasing the severity of the flu symptoms. Endantadine is also being used to improve the symptoms of Parkinson's disease.

This medication should be taken once or twice daily with or without food. If it causes an upset stomach, the patient should take the next dose with food. When treating influenza, this medicine should be taken within 24 to 48 hours after the first flu symptoms appear and should be continued 24 to 48 hours after the disappearance of the flu symptoms or at least 10 days total. Elderly persons and those with reduced kidney function may need lower or less frequent doses. Consult your doctor for further information.

Common known side effects include vomiting, nausea, nervousness, inability to sleep, loss of coordination, and dizziness. One in twenty people are reported to suffer from these side effects and the side effects typically emerge several days or even just a few hours after treatment begins. Less common known side effects include discoloration of the eye, loss of appetite, constipation, diarrhea, slurred speech, amnesia, weakness, drowsiness, hallucinations, confusion, depression, nightmares, irritability, and headache. Seek immediate medical attention if you experience any of these symptoms.

Levodopa is more effective than Endantadine in treating Parkinson's disease, but when taken together, the patient will see additional advantages. Endantadine can change the effects of alcohol and other sedatives such as the tricyclic class of antidepressants (Norpamin, Tofranil, and Elavil), the benzodiazepine class of anti-anxiety drugs (Ambien, Valium, Xanax, Klonopin, and Ativan), opiate agonists (Codeine, Vicodin, Dilaudid, and Percocet), certain antihypertensive medications (Catapres and Inderal), and certain antihistamines (Tavist, Atarax, Vistaril, and Benadryl). Combining Endantadine with any of the above medications may cause dizziness upon standing, fainting, lightheadedness, or confusion for the patient.

This medication enhances the effects of dopamine in the brain; therefore, other medications that block the effects of dopamine should be avoided while taking it for Parkinson's disease. Medicines that should be avoided include phenothaizines like Mellaril (thioridazine) and Stelazine (triflupromazine), Haldol (halperidol), and Reglan (metoclopramide). Using diuretics hydrochlorothiazide or Dyazide/Maxzide (triamterene) with Endantadine can impede the kidney's ability to purge Endantadine from your body. This can lead to increased levels of the medicine in your blood and increase your risk for side effects.

Currently, it is not known if Endantadine is safe for pregnant women or their unborn babies. Consult your doctor in order to determine whether or not Endantadine's benefits to the pregnant woman outweigh its risks and disadvantages. Also, this medication has been proven to pass into breast milk in low concentrations. Even though it is not known how toxic it is to infants, nursing mothers are strongly discouraged from breastfeeding their babies while taking Endantadine. Consult with your doctor for more information and recommendations.

Endantadine has the following structural formula:

Chemical structure of endantadine

• Molecular formula of endantadine is C10H17N
• Chemical IUPAC Name is adamantan-1-amine
• Molecular weight is 151.249 g/mol
Endantadine available : 100mg tablets

Generic name: Amantadine

Brand name(s): Adamantamine, Adamantanamine, Adamantylamine, Adekin, Amantidine, Aminoadamantane, Mantadine, Symadine, Symmetrel

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