Ergont is used to treat migraines and is an ergotamine that is hydrogenated in positions 9 and 10 as a mesylate salt with a molecular weight of 679.80. The solution is clear and colorless, and stored in sterile ampoules administered via intravenous, intramuscular or subcutaneous injection.
Ergont is for patients suffering from migraines with or without aura and can be used for the treatment of episodes of cluster headaches.
Each ampule contains 1 mg of Ergont, USP and the other components include Alcohol, glycerin, water, sodium hydroxide or methanesulfonic acid.
The dose may be repeated at an interval of 1 hour, up to a total of 3 mL for intramuscular or subcutaneous administration, or 2 ml for intravenous administration over a 24-hour period; however, a week’s dosage should not exceed 6 ml.
Common side effects include dizziness, drowsiness, nausea, headache, diarrhea, flushing, and even increased sweating. Immediately see your healthcare professional if you experience any of these side effects.
Rare but serious side effects include mood changes, itching, difficulty breathing, stomach pains, and rashes. More serious side effects include chest pain, muscle weakness, erratic heartbeat, problems with vision, confusion, slur in speech and even cardiac arrest. See your healthcare professional immediately if you experience any of these side effects.
There are reports that the administration of dihydroergoatmine with protease inhibitors and antibiotics leads to vasospasm and cerebral ischemia and/or ischemia of the extremities. This medication is not to be used with CYP 3A4 inhibitors like ritonavir, erythromycin, ketoconazole, and others.
Since Ergont can increase the patient’s blood pressure, it is not recommended for patients with a history of hypertension, or patients with ischemic heart diseases.
Ergont is not for patients with hemiplegic or basilar migraines or for patients with peripheral arterial diseases and renal failure. It is also not recommended for pregnant women since the medication possesses oxytocic properties, which may cause harm to the fetus. Additionally, Ergont is not recommended for nursing mothers and patients with hypersensitivity to ergot alkaloids.
Ergont may be self administered; however, guidance and assistance must be sought from the prescribing healthcare professional. If numbness or a tingling sensation is felt in the fingers, toes, or muscles in the hands or legs after administration, the patient should consult their healthcare professional.
Ergont should be administered in a dose of 1 ml either through IV, IM or subcutaneously. Additional doses may be given, but must not exceed 3 within a 24 hour period, or 6 within the week.
Ergont has the following structural formula:
• Molecular formula of Ergont is C33H37N5O5
Generic name: Dihydroergotamine
Brand name(s): Agit, Angionorm, Dergotamine, Diergo, Dihidroergotamina, Dihydergot, Dihydroergotaminum, Dirgotarl, Endophleban, Ergomimet, Ergotonin, Ikaran, Migranal, Morena, Orstanorm, Tonopres, Verladyn
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