Esomeprazole review

Esomeprazole belongs to a class of drugs termed as proton pump inhibitos (PPIs). PPIs work by discouraging the stomach from producing acids. Generally, PPIs are emplyed for the treatment of conditions like dyspepsia, stomach and duodenal ulcers, Zollinger-Ellison syndrome and more importantly, gastroesophageal reflux disease (GERD). Essentially, Esomeprazole is applicable to conditions which result from the corrosive quality of the stomach acids.

Esomeprazole was developed by the company, AstraZeneca. It was approved by the Food and Drug Administration in 2001.

This drug is very popular. In fact, in 2005, it was the third largest selling pharmaceutical drug in the entire world.

The capsules of Esomeprazole contains tiny enteric-coated granules. The esomeprazole formulation is inside the pellet and is covered by an outer shell. Once the capsule reaches the stomach, the liquids in the stomach will enter the capsule via osmosis. Eventually there will be too much water inside the capsule, causing it to burst and consequently, it will release all the granules. As such, the esomeprazole formulation will be released and it will begin to inhibit acid production and foster healing in the stomach.

Similar to other PPIs, Esomeprazole works by blocking the enzymes that are responsible for the production of the stomach’s acids. By doing so, the acid production is suppressed and the environment inside the stomach and esophagus becomes much more conducive to the healing of ulcers and sores. Also, when taken with other medications, Esomeprazole is able to reduce acid reduction to allow the other medications to effectively treat and existing sore or injury within the stomach area.

Since Esomeprazole can only decrease acid production, it cannot fully address certain conditions. So if the intention is to address ulcers or H.pylori infection, Esomeprazole must be taken with amoxicillin and clarithromycin. Once the infection is treated, conditions like ulcers will also be healed.

Esomeprazole is available for oral consumption, in the form of capsules with dosages of 20 and 40 mg. The same dosages may also be administered intravenously.

The dosage of Esomeprazole is dependent on the kind of condition the patient has. For gastroesophageal reflux disease (GERD), the patient may be asked to take either 20 or 40 mg tablets, once daily for up to eight weeks. Meanwhile, H.Pylori infection requires the patient to take a 40 mg Esomeprazole tablet daily for ten days. Again, for H. Pylori, Ezomeprazole must be taken with amoxicillin and clarithromycin.

The tablet or the IV must be administered an hour before mealtime.

Also, the patient must not forget that drinking Esomeprazole can affect any other medical treatment s/he is undergoing. The reduced acid levels will consequently affect the way the stomach is able to absorb other medications. As such, the effect of certain drugs may be weakened.

If there are no negative interactions with other drugs, Esomeprazole is, usually, well accepted by the body. If there are side effects, they are usually very mild. Some of the common side effects are diarrhea, headache, vomiting, dizziness. On certain cases, patients may also experience muscle pain, fatigue, leg cramp and bloatedness.

Esomeprazole has the following structural formula:

Chemical structure of esomeprazole

• Molecular formula of esomeprazole is C17H19N3O3S
• Chemical IUPAC Name is 5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-3H-benzoimidazole
• Molecular weight is 345.417 g/mol
Esomeprazole available : 20mg tablets, 40mg tablets

Brand name(s): Nexiam, Nexium, Prilosec, Zegerid

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