Estradiol, which is also prescribed as Estrace Vaginal Cream, is commonly used to treat symptoms of menopause such as itching, dryness, or burning of the vaginal area, as well as the urgent need to urinate and irritation while urinating.
Estradiol is not appropriate for everyone. A thorough medical history should be assessed prior to prescribing this medication. Patients with a medical history which includes a circulation disorder, bleeding disorder, blood clots, abnormal vaginal bleeding, breast cancer, uterine cancer, a hormone dependant cancer, high blood pressure, angina, heart disease, high cholesterol, high triglycerides, liver disease, kidney disease, asthma, migraines, epilepsy, gall bladder disease, diabetes, depression, hysterectomy, uterine fibroids, a narrow, short, or prolapsed vagina, vaginal infection, or vaginal irritation may not be able to take estradiol or may require careful monitoring while undergoing drug therapy with this medication, depending on the condition and the severity of the condition.
The American Food and Drug Administration rated estradiol as a pregnancy risk category X. Estradiol will cause harm or birth defects to an unborn baby. This medication does pass through the mother’s breast milk and is likely to affect a nursing baby. The prescribing physician should avoid prescribing this medication to women who are pregnant, nursing, or to women with a high likelihood of becoming pregnant.
There is a risk of side effects associated with estradiol, some of which are severe. A patient who is experiencing a serious side effect or an allergic reaction should seek immediate emergency medical attention. An allergic reaction will present with side effects such as facial swelling, including swelling of the lips, mouth, throat, or tongue, hives, and difficulty breathing. Other serious side effects which require immediate emergency medical attention include symptoms such as chest pain, shortness of breath, a painful, red, and swollen leg, abnormal vaginal bleeding, pain, swelling, or tenderness of the abdomen, severe headache, vomiting, dizziness, fainting, changes in vision, difficulty with speech, jaundice, or a lump in the breast.
Less serious side effects typically do not require emergency medical attention but should be reported to the prescribing physician. Patients should be encouraged to report all side effects. Less serious side effects include symptoms such as sexual dysfunction, swollen breasts, loss of appetite, mild nausea or vomiting, migraine headaches, dizziness, vaginal discomfort, dryness, or pain, water retention, depression, or changes in the menstrual cycle and breakthrough bleeding. Less serious side effects can often be reduced to a tolerable level by reducing the dosage of estradiol.
Estradiol should be taken exactly as it has been prescribed by the physician. If the patient misses a dose, the dose should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped to avoid the potential for an overdose. The patient should never take a double dose of this medication. If an overdose is suspected, the patient should seek immediate emergency medical attention. An overdose will present with symptoms such as vaginal bleeding, severe irritation, possible changes in heart rhythm, or headaches, nausea, and vomiting. An overdose of this medication is highly unlikely.
There is a potential risk of negative drug interactions associated with estradiol. A thorough medical history should be understood prior to prescribing this medication. Patients should be urged to inquire with the prescribing physician before taking any new medications, including over the counter medications and herbal remedies. Medications with a known negative drug interactions with estradiol include anti-coagulants such as warfarin, thyroid medication, insulin, oral diabetes medications, and tamoxifen.
Estradiol has the following structural formula:
• Molecular formula of estradiol is C18H24O2
• Chemical IUPAC Name is 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
• Molecular weight is 272.382 g/mol
• Estradiol available : 0.1mg/gm cream 42.5gm tube, 0.5mg tablets, 1mg tablets, 2mg tablets
Brand name(s): Aerodiol, Agofollin, Alora, Altrad, Amnestrogen, Aquadiol, Bardiol, Beta-Estradiol, Cis-Estradiol, Cis-Oestradiol, Climaderm, Climara, Combipatch, Compudose, Corpagen, D-Estradiol, D-Oestradiol, Delestrogen, Depo-Estradiol, Dermestril, Dihydrofolliculin, Dihydromenformon, Dihydrotheelin, Dihydroxyesterin, Dihydroxyestrin, Dihydroxyoestrin, Dimenformon, Diogyn, Diogynets, Divigel, Encore, Esclim, Estinyl, Estrace, Estraderm, Estradurin, Estraldine, Estrasorb, Estreva, Estrifam, Estring, Estroclim, Estrogel, Estrol, Estrovite, Evex, Evorel, Extrasorb, Femestral, Femestrol, Feminone, Femogen, Fempatch, Femring, Femtrace, Femtran, Follicyclin, Ginedisc, Ginosedol, Gynergon, Gynestrel, Gynodiol, Gynoestryl, Gynpolar, Innofem, Lamdiol, Lynoral, Macrodiol, Macrol, Menest, Menorest, Menostar, Microdiol, Nordicol, Oestergon, Oestradiol, Oestrogel, Oestroglandol, Oestrogynal, Ovahormon, Ovasterol, Ovastevol, Ovociclina, Ovocyclin, Ovocycline, Ovocylin, Perlatanol, Primofol, Profoliol, Progynon, Ricifon, Ritsifon, Sk-Estrogens, Soldep, Sotipox, Syndiol, Systen, Tradelia, Trial Sat, Trocosone, Vagifem, Vivelle, Zerella, Zumenon
Review published on: 08 April 2007
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