Eucardion review

Eucardion, a substance derived from EDTA, is believed to interfere with substances inside cells, which may cause heart illness after using anthracyclines such as doxorubicin. How Eucardion protects the heart is not fully understood. This medication is available as Zinecard in the United States and Canada, and Cardiozane in the EU and comes in 250 mg and 500 mg vials for injection.

Eucardion is used to prevent and reduce the severity of heart conditions, which can occur during chemotherapy using anthracyclines, such as those used in the treatment of women suffering from metastatic breast cancer.

Eucardion has been approved for use as a treatment of extravasation caused by anthracycline chemotherapy. Extravasation occurs when anthracycline leaks out of the blood vessels and seeps into the skin.

Dosage depends on the body surface area of the affected role and the doxorubicin dose being taken. It is typically measured in a 10:1 ratio with respect to the doxorubicin dose. Once the proper dose has been determined, the medication can be administered directly into the vein via an IV push or through a quick infusion from an IV infusion bag. About 30 minutes after taking Eucardion, the IV injection of doxorubicin can be given.

Eucardion is stable for about 6 hours after reconstitution when placed in an empty infusion bag at controlled room temperature ranging from 15 to 30C (59 to 86F), or placed in refrigeration at 2 to 8C (36 to 46F). It may be diluted using a 0.9% sodium chloride injection, USP or using a 5.0% dextrose injection, USP. Dilute the medication to a concentration between 1.3 to 5.0 mg/mL and store in empty IV infusion bags. Do not use leftover solutions.

The most common side effects experienced during Eucardion treatment is pain or skin edema at the injection site. Blood counts can also be lower when taking Eucardion with chemotherapy compared to undergoing chemotherapy alone. Recovery periods for the blood counts are similar for both cases.

Other common side effects include diarrhoea, general discomfort, pyrexia, loss of appetite and wamble. More serious side effects involve baldness, vomiting, skin edema of the throat and tongue, and severe allergic reactions that require immediate medical attention.

Eucardion should only be used with anthracycline chemotherapy such as doxorubicin.

Chemotherapy can cause sterility in men and women so consult your physician if you plan on having children. It has not been shown that Eucardion itself can cause sterility. If you believe you may be pregnant, inform your physician about your condition before being given Eucardion.

You may experience greater susceptibility to infection during treatment so consult with your physician before getting vaccines to avoid complications.

Eucardion has the following structural formula:

Chemical structure of Eucardion

• Molecular formula of Eucardion is C11H16N4O4
• Chemical IUPAC Name is 4-[1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione
• Molecular weight is 268.269 g/mol
Eucardion available : 250mg injection and 500mg injection

Generic name: Dexrazoxane

Brand name(s): Cardioxane, Desrazoxane, Dexrazoxano, Dexrazoxanum, Dextrorazoxane, Dyzoxane, Razoxana, Razoxane, Razoxanum, Razoxin, Tepirone, Troxozone, Zinecard

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