Fenofibrate review

Fenofibrate belongs to the fibrate class of drugs. It is primarily used to decrease the cholesterol levels of people who are at risk for cardiovascular diseases. Just like any other fibrates, Fenofibrate reduces triglycerides, low and very low-density protein. It also increases high density lipoprotein levels in the body. Fenofibrate is also known to have a beneficial effect on insulin resistance related to metabolic syndrome.

Fenofibrate may be used alone or with statins in treating hypertriglyceridemia and hypercholesterolemia. This drug is sold under the brand name Lipanthyl by Solvay Pharmaceutical and Tricor by Abbott Labs. This drug is commonly used in medical conditions that involve diet changes to help reduce the amount of cholesterol and triglycerides in the blood. By lowering the blood level of fats and cholesterol, heart diseases, angina, heart attacks and strokes may be prevented.

The dosage of Fenofibrate may vary on the form and strength of different brands. In the United States, Tricor is available in tablet forms of 48 mg and 145 mg. In Europe, Fenofibrate is available in capsule and also in coated tablet. The strength range of Fenofibrate in Europe include 67, 145, 160 and 200 mg. Altered bioavailability due to particle size is responsible for the differences in strength. Fenofibrate is taken by mouth and is usually taken once a day on a full stomach. It is not advisable to discontinue the intake of Fenofibrate with consulting a doctor.

Like other fibrates, Fenofibrate acts on peroxisome proliferator-activated receptors to reduce cholesterol levels in the body. Fenofibric acid is the active ingredient in Fenofibrate. Fenofibric acid inhibits the synthesis of cholesterol and facilitates the elimination of cholesterol as bile salts.

Before taking Fenofibrate, you should tell your doctor if you are allergic to Fenofibrate, other fibrates and drugs. You should also inform your doctor if you are taking anti-coagulants, reductase inhibitors, cholestyramine, cyclosporine, and other herbal products and supplements. Being open to your doctor about your additional medications and supplements is very important so that there will be lesser chances of drug complications.

If you are taking Fenofibrate, try to have a low-fat and low-cholesterol diet that includes fat-free milk, cottage cheese, vegetables, fish, egg whites, poultry and poly-saturated margarines and oils. Foods that are high in fat and cholesterol should be highly avoided such as meat, whole milk, egg yolks, butter, cream, pastries, shortening, cakes, gravy, peanut butter, cookies, chocolates, potato chips, olives, cheese, coconut oil, fried foods and palm oil.

The most common side effects of Fenofibrate include gas, runny nose, headache, fatigue, stomach pain, constipation, upset stomach, dizziness or light-headedness. More serious side effects of Fenofibrate include weakness, flu-like symptoms, muscle pain or tenderness, infection, joint pain and rashes. If the symptoms are very intense and persistent, it is best to go to a doctor immediately so that proper medical attention could be given to the patient.

It is not advisable to just ignore the aversive symptoms because it may lead to complication and other serious health problems.

Fenofibrate has the following structural formula:

Chemical structure of fenofibrate

• Molecular formula of fenofibrate is C20H21ClO4
• Chemical IUPAC Name is 1-methylethyl2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoate
• Molecular weight is 360.831 g/mol
Fenofibrate available : 200mg capsules, 160mg tablets

Brand name(s): Ankebin, Antara, Elasterate, Elasterin, Fenobrate, Fenofibrato, Fenofibratum, Fenogal, Fenotard, Finofibrate, Lipanthyl, Lipantil, Lipidex, Lipidil, Lipifen, Lipirex, Lipoclar, Lipofene, Liposit, Lipsin, Lofibra, Luxacor, Nolipax, Procetofen, Proctofene, Protolipan, Secalip, Sedufen, Tricor, Triglide

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