Florinef review

Florinef is a brand name for fludrocortisone acetate, which is a synthetic adrenocortical steroid. It is prescribed for the treatment of adrenocortical insufficiency such as that characteristic of Addison’s disease, and for the treatment of salt-losing adrenogenital syndrome. In Addison’s disease, your adrenal glands produce too little cortisol, and sometimes insufficient aldosterone, which can be life-threatening. Florinef is available in tablets, but the dosage depends on the severity of the disease and the way each individual patient responds. Your doctor will monitor you for signs that may indicate that you need your dosage adjusted.

Florinef, like most medications, can cause side effects. The most serious of these are caused by the retention of sodium and water and can include high blood pressure, enlarged heart, potassium loss, swelling of the legs and feet, imbalance of the blood’s acids, and congestive heart failure. Other side effects can include muscle weakness, loss of muscle mass, osteoporosis, compression fractures in the vertebrae, fractures of the longer bones, or spontaneous fractures. You may also experience peptic ulcers, pancreatitis, abdominal distention, ulcerative esophagitis, bruising, red spots on the skin, slowed healing of wounds and injuries, increased sweating, excessive hair growth, hives, darkening of the skin, convulsions, increased pressure inside the skull, headache, severe mental disturbances, menstrual irregularities, decreased tolerance of carbohydrates, glaucoma, increased blood sugar levels, rash, insomnia, and aggravation of infections. Florinef may also worsen cataracts and glaucoma and make you more susceptible to eye infections. You may also gain a great deal of weight, especially as you retain salt and water. You should discuss with your doctor if you experience any of these side effects.

There are some drugs that may interact negatively with Florinef. These include diuretics which deplete your blood’s potassium levels; your doctor may want to monitor your potassium levels while you are taking Florinef. Other drugs that may react with Florinef include anticoagulants, which keep your blood from clotting, diabetes drugs including insulin, aspirin, barbiturates, anabolic steroids, vaccines, and estrogen. Florinef should not be used to treat any other disorders because of the risks involved in sodium retention. Your doctor may want to test your electrolytes regularly to make sure you remain at healthy levels.

Children who are taking Florinef may be more susceptible to infections than other children are. Every precaution should be taken to keep these children from catching bacterial or viral infections, as their immune systems will be weakened and these illnesses can cause severe complications. There have been no conclusive studies regarding the safety of Florinef for pregnant women or their babies. It is known, however, that even small doses of corticosteroids can produce birth defects in animals. It is not recommended that Florinef be used for pregnant women, so be sure to inform your doctor if you are pregnant or planning to become pregnant. It is known that corticosteroids can be found in breast milk, and can have negative effects on babies. You and your doctor may have to decide whether to discontinue Florinef or to discontinue nursing.

Florinef has the following structural formula:

Chemical structure of florinef

• Molecular formula of florinef is C21H29FO5
• Chemical IUPAC Name is 9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl- 1,2,6,7,8,9,10,11,12,13,14,15,16,17- tetradecahydrocyclopenta[a]phenanthren-3-one
• Molecular weight is 380.45 g/mol
Florinef available : 0.1mg tablets

Generic name: Fludrocortisone

Brand name(s): Alflorone, Astonin-H, F-COL, F-Cortef, Fludrocortisona, Fludrocortisonum, Fludrocortone, Fludrone, Fludronef, Fluodrocortisone, Fluohydrisone, Fluohydrocortisone, Fluorocortisol, Fluorocortisone

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