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Fluconazole

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Fluconazole

Fluconazole review





Fluconazole is a triazole antifungal drug used to treat and prevent systemic and superficial fungal infections. In a form of bulk powder, the drug appears to be a clump of white crystalline powder. It is soluble in alcohol and very slightly soluble in water. Fluconazole is basically marketed under the trade names Trican (Pfizer) or Diflucan. Fluconazole fights the following microorganisms: Blastomyces dermatitidis, trichophyton spp., candida spp., microsporum spp., coccidioides immitis, histoplasma capsulatum, cryptococcus neoformans and epidermophyton spp.

This drug is prescribed by doctors to treat and rid the body system of fungal infections that other anti-fungals cannot eradicate such as Candidiasis, Tinea corporis, Tinea cruris, Tinea pedis, Onychomycosis, Cryptococcal meningitis, Coccidioidomycosis, Cryptococcosis, and Histoplasmosis.

In layman’s term, Fluconzaole treats fungal infections that occur around the mouth, vagina, throat, abdomen, esophagus, blood, lungs, and other organs. Fluconazole is also prescribed to patients who are likely to become infected with yeast infection such as those who are undergoing radiation therapy or chemotherapy.

The dosage of Fluconazole varies with the intensity of the fungus as well as with the age of the patients. For vulvovaginal candidiasis, a two-week course of 150 mg/day is needed. For persistent skin infections, 150-300 mg once weekly is needed. For severe or systemic infections, 50–600 mg/day of Fluconazole may be used. For meningitis caused by yeast, 800 mg dose of Fluconazole is usually prescribed. For pediatric patients, low doses are prescribed ranging from 6-12 mg/kg/d.

It is highly advisable not to take any prescribed drugs immediately; make sure that you inform your doctor and pharmacist of allergies to certain drugs so that there will be less chances of encountering health complications in the future. If you are allergic to Fluconazole and other anti-fungal medications such as ketoconazole, itraconazole and voriconazole, tell your doctor or pharmacist prior to your drug intake.

Do not take cisaprise (Propulsid) while you are taking Fluconazole. Inform your doctor immediately if you have accidentally taken Fluconazole and Propulsid together.

Tell your doctor if you have been taking drugs and medications that include amiodarone, anticoagulants, astemizole, benzodiazepines, cyclosporine, disopyramide, diuretics, dofetilide, erythromycin, isoniazid, moxifloxacin, oral contraceptives, oral medicines for diabetes, phenytoin, pimozide, procainamide, quinidine, rifabutin, rifampin, sotalolol, sparfloxacin, tacrolimus, terfenadine, theophylline, thioradazine, valproic acid or zidovudine.

You should also tell your doctor if you have ever drunk or drink large amounts of alcohol, have ever had or have cancer, acquired immunodeficiency syndrome, palpitations or irregular heartbeat, and kidney, heart or liver disease.

Common side effects of Fluconazole include change in ability to taste food, headache, heartburn, dizziness, stomach pain and diarrhea. Some side effects can be fatal and dangerous and if ever you feel one of the following symptoms, call a doctor immediately: upset stomach, difficulty breathing or swallowing, extreme tiredness, swelling of some parts of the body, unusual bleeding or bruising, itching, lack of energy, loss of appetite, rashes, pain in the upper right part of the stomach, seizures, yellowing of the eyes or skin, pale stools, flu-like symptoms, and dark urine.

Fluconazole has the following structural formula:

Chemical structure of fluconazole


• Molecular formula of fluconazole is C13H12F2N6O
• Chemical IUPAC Name is 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• Molecular weight is 306.271 g/mol
Fluconazole available : 10mg/ml suspension 35ml bottle, 50mg tablets, 150mg tablets, 100mg tablets, 200mg tablets

Brand name(s): Biocanol, Biozolene, Diflucan, Elazor, Flucazol, Flucostat, Flukezol, Flunizol, Flusol, Pritenzol, Triflucan

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