Flunarizine review

Flunarizine is a calcium channel blocking drug that was discovered in 1967 at Janssen Pharmaceutica. It is primarily used by migraine patients to reduce the frequency and severity of attacks. It is also prescribed to patients with peripheral vascular disease, vertigo, and epilepsy.

Flunarizine works by affecting the movement of calcium, relaxing the blood vessels in the process. It also helps increase the supply of oxygen to the heart and decrease its workload.

Before deciding to use Flunarizine or any of the calcium channel blocking agents for that matter, make sure that you have discussed it with your doctor. Since the medicine can cause several physical discomforts as side effects, you need to establish -- with the help of your doctor – its benefits. The good that Flunarizine could do in treating your condition must outweigh every possible consequence that comes with it.

To ensure that you are safe with the drug, you must talk to your doctor about your medical history. He will ask you about existing allergies to drugs or any of its components. An allergic reaction against Flunarizine may induce more severe side effects. It is also important that your doctor know all the drugs – prescription and non-prescription – that you are currently using to ensure that none of them will encourage drug interactions. Your doctor would also need to know if you are planning to become pregnant, are actually pregnant, or have just given birth. The use of Flunarizine may cause birth defects in unborn babies and may also cause problems in newborn babies. Age is also an issue here. While use of Flunarizine in children does not pose any problem, use in elderly does. Doctors are mostly cautious in prescribing this medicine to people who are aged 50 an above. Their sensitivity to the effects of Flunarizine may result in adverse side effects. The doctor may advise a lower dose, which will be gradually increased as the body becomes adjusted to the drug. The presence of other medical conditions involving the heart, the liver, and the kidney may also affect the effectiveness of the drug. Flunarizine is also not ideal to use in patients with Parkinson’s disease.

Flunarizine is an oral drug that comes in 10mg capsules. The usual dosage for adults is one capsule a day. For young children, the dosage must be arranged directly by your doctor. Flunarizine must be taken in the evening. To reduce the possibility of missing a dose, take it at about the same time each day. If you happen to miss a dose, take Flunarizine as soon as you remember it, considering that it is not too close to your next dosing schedule. In case of the latter, it is better that you skip the missed dose and continue with your regular schedule.

At the start of a Flunarizine treatment, you may experience some side effects, which are normal since your system is still adjusting to the drug. These side effects include drowsiness, heartburn, weight gain, and dry mouth. Remember not to participate in any activity that needs your alertness until you are able to adjust to the drug. Your drowsiness may affect your driving skills as well as your ability to operate machines. If you feel that your symptoms of side effects overpower the positive effects of Flunarizine, call your doctor immediately.

Flunarizine has the following structural formula:

Chemical structure of flunarizine

• Molecular formula of flunarizine is C26H26F2N2
• Chemical IUPAC Name is 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
• Molecular weight is 404.4948 g/mol
Flunarizine available : 5mg tablets, 10mg tablets

Brand name(s): Flufenal, Flunarizina, Flunarizinum, Fluvert, Issium, Novo-Flunarizine, Sibelium, Vertix, Zinasen

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