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Fluoxetine

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Fluoxetine

Fluoxetine review





Fluoxetine is the generic equivalent of Prozac and Sarafem, which is commonly prescribed to treat the symptoms of depression, bulimia, obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder. Fluoxetine is a member of the antidepressant family known as SSRI, or selective serotonin reuptake inhibitors.

Fluoxetine is not appropriate for everyone. A thorough medical history should be assessed prior to prescribing this medication. Patients with a medical history that includes kidney disease, diabetes, cirrhosis of the liver, seizures, epilepsy, bipolar disorder, or a history of suicidal thought or self harm may not be able to take Fluoxetine or may require careful monitoring while undergoing drug therapy with Fluoxetine. Patients who have taken an MAOI in the previous 14 days can not take Fluoxetine.

The American Food and Drug Administration has given Fluoxetine a pregnancy risk rating category C, which means that this medication is likely to cause harm or birth defects to an unborn baby. Fluoxetine has been proven to cause lung problems in newborns exposed to this medication while in the uterus. Fluoxetine will pass through the mother’s breast milk and may affect a nursing baby. The prescribing physician should avoid prescribing this medication to pregnant or nursing women, or to women who are likely to become pregnant.

Fluoxetine carries a risk of side effects, some of which are severe. A patient experiencing a serious side effect or an allergic reaction should seek immediate emergency medical attention. An allergic reaction will present with symptoms that include facial swelling, including swelling of the lips, mouth, tongue, or throat, hives, and difficulty breathing. Other serious side effects which require emergency medical intervention include symptoms such as convulsions, tremors, twitching, shivering, muscle stiffness, red or blistering or peeling skin rash, unusual thoughts, uncharacteristic behavior, lack of coordination or balance, agitation, confusion, sweating, or fast heart rate.

Other less serious side effects typically do not require emergency medical attention but should be reported to the prescribing physician. Patients should be encouraged to report all side effects. Less serious side effects include symptoms such as drowsiness, weakness, dizziness, anxiousness, nervousness, restlessness, runny nose, sore throat, cough, flu symptoms, headaches, nausea, diarrhea, changes in appetite, weight changes, dry mouth, sweating, and sexual dysfunction. Less serious side effects can often be reduced to a tolerable level by reducing the dosage of Fluoxetine.

Fluoxetine should be taken exactly as it has been prescribed. If the patient misses a dose, the dose should be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped to avoid the potential for an overdose. The patient should never take a double dose of Fluoxetine. If an overdose is suspected, the patient should seek immediate emergency medical care. An overdose will present with symptoms that include nausea, vomiting, sleepiness, dizziness, fever, rapid heart beat, uneven heart rate, confusion, fainting, seizures, hallucinations, coma, and death.

There is a risk of negative drug interactions associated with Fluoxetine. A thorough medical history should be understood prior to prescribing this medication. Patients should be urged to inquire with the prescribing physician before taking any new medication, including over the counter medication and herbal remedies. Medications that are known to cause negative interactions with Fluoxetine include alprazolam, clozapine, digitoxin, flecainide, haloperidol, tryptophan, seizure medications, vinblastine, blood thinners, almotriptan, pimozide, thioridazine, MAO inhibitors, and any other antidepressant. Many of these interactions can result in permanent brain damage or death.

Some patients become suicidal while taking this medication, especially in the early stages or after long term use. The prescribing physician should keep constant evaluation of the patient’s mental state, especially in patients under eighteen. This medication is not recommended for children under eighteen.

Fluoxetine has the following structural formula:

Chemical structure of fluoxetine


• Molecular formula of fluoxetine is C17H18F3NO
• Chemical IUPAC Name is N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine
• Molecular weight is 309.326 g/mol
Fluoxetine available : 10mg tablets, 20mg tablets, 90mg capsule

Brand name(s): Animex-On, Deprex, Eufor, Fluctin, Fluoxeren, Fluoxetina, Fluoxetinum, Fluval, Fontex, Foxetin, Portal, Prozac, Pulvules, Reneuron, Sarafem

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