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Fondaparinux sodium

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Fondaparinux sodium

Fondaparinux sodium review





Fondaparinux sodium belongs to the group of drugs called heparinoids or blood thinner. It helps in preventing the development of blood clots after a knee or hip surgery.

This medicine is popularly known as Arixtra. It is given to individuals who have undergone surgeries such as knee replacement and hip fracture and abdominal operations to reduce the risks of blood clots. Blood clots can go to the heart, lungs, and brain when left untreated which can result to severe cases of breathing difficulties, stroke, and heart attack.

Fondaparinux sodium is administered intravenously. Before injecting a dose, the area to be injected should be cleaned with rubbing alcohol. It is also recommended that the site of the injection is changed daily to avoid problematic areas under the skin.

Before using Fondaparinux sodium, users should check the product for any discoloration. It should not be used if there is any discoloration, nor mixed with any drug in similar type of injection.

Fondaparinux sodium is usually injected in the skin just below the stomach or abdomen area. It should never be injected into a muscle group.

The initial dosage of Fondaparinux sodium is 2.5 milligrams taken once a day. The dosage is increased thrice a day once hemostasis is established. This usually lasts 9 days after the therapy. For those who have undergone hip fracture operation, the treatment can take up to 32 days.

The dosage and duration of the treatment may vary according to the condition of the patient and his or her response to the medication. It can also vary according to the patient’s weight.

To help patients remember taking Fondaparinux sodium, it is recommended that they take the drug at the same time every day.

Some of the more common side effects that users of Fondaparinux sodium experience are pain, redness, bruising and swelling at the area of injection. Users may also experience nausea, headache, vomiting, swollen feet and hands, or fever. In case any of these side effects persist, users should immediately inform their physicians.

Users should immediately tell their doctors in case any of these severe side effects appear- unexplained bruising and bleeding, difficulty in breathing, chest pains, coughing up of blood, unexplained dizziness, irregular heart beat, pain in the joint and muscles, black stool, pinkish urine, and changes in mood.

It is very rare for users of Fondaparinux sodium to experience any symptom of allergic reaction. However in case any of these symptoms occur- rashes, swelling, and itching- persist, users should immediately seek medical help.

Patients should inform their doctor or pharmacist if they are allergic to blood thinners, NSAIDs, and sulfinpyrazone before agreeing to take Fondaparinux sodium.

Those who have blood or bleeding problems like low blood count; blood clotting ailment due to heparin; eye problems; kidney disease; high blood pressure; seizures; and intestinal problems are also cautioned into taking Fondaparinux sodium. The same goes for those who have had stroke, recent surgery on the brain, spine, and eye, and body weight of less than 110 pounds.

Fondaparinux sodium has the following structural formula:

Chemical structure of fondaparinux sodium


• Molecular formula of fondaparinux sodium is C31H43N3Na10O49S8
• Chemical IUPAC Name is decasodium (2R,3S,4S,5R,6R)-3-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6S)-6- carboxylato-5-[(2R,3R,4R,5S,6R)- 4,5-dihydroxy-3- (sulfonatoamino)-6-(sulfonatooxymethyl)oxan-2-yl]oxy-3,4- dihydroxy-oxan-2-yl]oxy-3-(sulfonatoamino)-4- sulfonatooxy-6-(sulfonatooxymethyl)oxan-2-yl]oxy- 4-hydroxy-6-[(2R,3S,4R,5R,6S)-4-hydroxy-6- methoxy-5-(sulfonatoamino)-2-(sulfonatooxymethyl) oxan-3-yl]oxy-5-sulfonatooxy-oxane-2-carboxylate
• Molecular weight is 1726.77 g/mol

Brand name(s): Arixtra, Fondaparinux

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