is used to prevent ulcers in the stomach
and small intestines, gastroesophageal reflux disease, upper GI bleeding and acid reflux. This medication is also used to prevent aspiration of pneumonia
and stress ulcers, and herpes virus infection and can be used prior to anesthesia
to prevent aspiration pneumonitis.
Gastromet blocks histamine, which is responsible for releasing acid into the stomach. Tagamet is the brand name and is available in tablet or liquid form. Gastromet is taken by mouth
with or without food. Do not take any antacids one hour before or after taking this medication. Cephalosporin, itraconazole
should be taken two hours prior to taking Gastromet. If a dose is missed, take it as soon as remembered, but do not take more of the medication than prescribed at one time.
Gastromet is classified by the FDA in pregnancy category B. This medication can be excreted in breast
milk so nursing mothers will need to consult their healthcare professional regarding the safety of the baby before taking this medication. It is important that the healthcare professional be informed if the patient is pregnant, plans to become pregnant or is nursing an infant. The healthcare professional should also know if the patient is allegeric to any ingredients in Gastromet. Extreme caution must be observed when prescribing this medication to the elderly, as they may have reduced renal function. Caution is also necessary when prescribing this medication to patients under 16 years old, as it has not been established for safety and efficacy for this age group.
Some negative interactions may occur while taking this medication. If you are taking medicine for cancer
, high blood pressure
, erectile dysfunction
or if they are taking cisapride
or nitrosoureas, you cannot take this medication. Antacids, anticholinergics, or metoclopramide
may inhibit the body from properly absorbing the Gastromet. Gastromet may reduce the effectiveness of the following medications: tricyclic antidepressants, calcium
channel blockers, quinine and caffeine. If taken with carmustine
marrow toxicity might be enhanced. This medication will not interfere with lab testing. Patients should not take over-the-counter medications, herbal medicines or dietary supplements without their healthcare professional’s consent. Some counseling regarding lifestyle changes, stress reduction and dietary changes (no spicy foods or alcohol) is suggested. Laboratory testing and follow-up visits are important to monitor the effectiveness of the medication. Smoking cessation
is highly recommended since smoking will reduce the ulcer healing effects of Gastromet.
and drowsiness may occur so patients are advised not drive or perform highly complicated tasks until they know how they are affected while taking this medication. If you experience any black tarry stool, abdominal pain, confusion
or coffee-ground emesis, notify your healthcare professional immediately. Severe side effects include breast enlargement or lumps, anxiety
, agitation, diarrhea
, bronchospasms, fatigue, hallucinations
, hair loss
or muscle pain
, loss of libido or cardiac arrhythmias. If an overdose is suspected, immediately take the patient to the emergency room or contact a local poison control center. Symptoms of an overdose include nausea
with coffee ground substance, hallucinations, diarrhea, and severe anxiety or emotional disturbance.
Gastromet has the following structural formula:
• Molecular formula of gastromet is C10H16N6S
• Chemical IUPAC Name is 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine
• Molecular weight is 252.34 g/mol
• Gastromet available : 300mg tablets, 400mg tablets