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Gengraf

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Gengraf

Gengraf review





Gengraf is an immunosuppressive medicament. Its most popular use is in combating organ rejection for patients who just had an organ transplant - skin, pancreas, small intestine, kidney, lung, heart, and bone marrow. By suppressing the activity of the immune system, Gengraf helps the replaced organ work well with the physical structure's system.

GENGRAF ACTION

Discovered in the early 1970s, Gengraf made transplantation possible without increased risk of morbidity. At first, the medicament was intended for antimicrobial use. When its immunosuppressive properties were recognized, immunological tests and investigations were soon initiated. The first successful use of Gengraf to an organ transplant patient occurred on March 9, 1980. Three years after, in 1983, Gengraf was approved for clinical use.

Aside from its role in transplantation, Gengraf is also effective as a treatment for Psoriasis, Rheumatoid Arthritis, and Atopic Dermatitis. It has also been found useful in protecting injury patients from brain damage. Gengraf as a treatment for Psoriasis is found to be the safest and quickest with very mild side effects, especially when used for a short period of time.

GENGRAF DOSAGE

Gengraf comes in capsule and liquid suspension to be taken orally twice a day. The dosage requirement is different for every patient. Some of the factors that determine the prescription include the patient's condition, blood pressure, weight, and how well their kidneys are working. At any point within the medicament period, the doctor may adjust the dose depending on the patient's response to the medicament. Normally, patients who are being treated with Gengraf are required to take blood tests every so often. This is to monitor the levels of the medicine obtained in the blood. It is advisable that you take Gengraf after the blood test. If you missed a dose, take it as soon as you realize it. However, if the missed dose is too close to the next scheduled dose, it is better that you discard the missed dose and proceed with your normal dosing schedule.

GENGRAF SIDE EFFECTS

As mentioned above, Gengraf is found to be very effective with mild side effects. Some of the mild side effects that are usually experienced by patients who are taking it for a short period include headache, wamble, joint pain, and gum swelling. Gengraf can also elevate the patient's cholesterol and triglycerides level as well as blood pressure. It is important that you be closely monitored by your doctor while undergoing Gengraf treatment.

GENGRAF PRECAUTIONS

There are a couple of precautions you need to take while undergoing Gengraf treatment to be on the safe side. Do not take any new medicines without the knowledge of your doctor. Medication interactions may cause damage to your health; it can even be fatal. So it is important that you take extra care. Also, you must not have grapefruit or grapefruit juice while taking Gengraf. Grapefruit interferes with the levels of Gengraf obtained in your blood.

Always wait for your doctor's instructions. Do not stop or continue taking the medicine without your doctor's advice. Also, take note of the physical discomfort that taking the medicine brings. Persistence of side effects, especially if it is greater than the benefits that you get from the medicament, must be taken to your doctor's attention.

Gengraf has the following structural formula:

Chemical structure of gengraf


 Molecular formula of gengraf is C62H111N11O12
 Chemical IUPAC Name is 30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
 Molecular weight is 1202.61 g/mol
 Gengraf available : 25mg capsules, 100mg capsules

Generic name: Cyclosporine

Brand name(s): Neoral, Restasis, Sandimmune

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