Glimicron review

Glimicron belongs to a class of drugs known as sulfonylureas. Sulfonylureas are a type of anti-diabetic drugs used in the management of type 2 diabetis mellitus, or the adult-onset diabetis. The main action of the drug is to increase the release of insulin in the beta cells found in the pancreas. Glimicron has been considered a first-generation sulfonylureas.

Glimicron is indicated for the treatment and the control of elevated blood sugar levels or hyperglycemia, a type of adult-onset diabetes that is Glimicron-responsive and ranges from stable, mild or non-ketosis prone. The use of Glimicron comes in when the diabetes could no longer be controlled by diet and exercise, or when the use of insulin therapy is not recommended. Glimicron is not distributed in the United States and the Philippines, and is available in different countries under the brand names Diamicron and Dianorm, Remicron, Diabeton, Diaprel, and Dianormax.

Glimicron is taken orally and is available in formulations of 40 to 320 mg. The dosage ranges from these amounts, and may be taken once or twice daily before eating. The dosage of the drug must not exceed 160 mg at one time.

Common side effects of the use of the drug include gastrointestinal pain such as diarrhea, nausea and vomiting. Allergic reactions such as swelling of the face, lips, throat, rashes and hive may also be experienced as side effects of the drug. Symptoms accompanied by hyperglycemia and hypoglycemia may also be experienced.

Elevated or lowered blood sugars, and complications arising from these conditions (shaking, headaches, cold skin and sweat, and anxiety) are also noted side effects of the drug. Hypoglycemia or low blood sugar may occur if taking Glimicron with missed or delayed meals. Too much exercise may also aggravate some drug effects and produce diarrhea, vomiting, and nausea.

Elevated blood sugar levels or hyperglycemia may also occur if not enough dosage of the drug is taken, or if the patients eat more than usual or exercises less. Symptoms include increase in thirst, hunger and urination.

The drug is contraindicated in patients with a known sensitivity to the drug, its components or any sulfonylureas. It is also contraindicated in patients with severe kidney, liver and heart failure, and for patients with Type I diabetis mellitus.

Caution is advised when administering the drug to geriatric patients as older people may have stronger reactions to the drug, and thus, may require reduced doses.

It is not known whether Glimicron causes harm to the unborn baby. For treating pregnant patients with diabetis, it is usually insulin which used as a primary drug of choice. The doctor must always be consulted prior to the sue of the drug, especially if you are pregnant or planning to get pregnant. As other drugs may be excreted in breast milk, a nursing mother must always weigh the potential benefits of the drug against the risks it may bring to her and her baby.

Glimicron has the following structural formula:

Chemical structure of glimicron

• Molecular formula of glimicron is C15H21N3O3S
• Chemical IUPAC Name is 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
• Molecular weight is 323.4110 g/mol

Generic name: Gliclazide

Brand name(s): Diamicron, Gliclazida, Gliclazide M, Gliclazidum, Nordialex

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