Glyburide review

Glyburide belongs to a class of medications known as sulfonylureas. This drug is used in the treatment of type 2 diabetes, an ailment in which the hormone insulin is improperly utilized in the body, making it difficult to regulate blood sugar levels. It is particularly helpful for type 2 diabetes sufferers who are unable to control their condition through a restricted diet alone.

In order for Glyburide to work, the pancreas needs to be able to secrete insulin, as opposed to type 1 diabetes where the pancreas is unable to produce any insulin at all. Glyburide promotes the regulation of blood sugar levels by stimulating the pancreas to produce additional insulin, as well as helping the body utilize it more efficiently.

It is regularly used in combination with diet, exercise and insulin treatments to combat the effects of hypoglycemia (low blood sugar), such as headaches, weakness and drowsiness, dizziness, palpitations, tremors, sweating and nausea.

Before taking Glyburide, patients will need to inform their doctor if they are currently suffering from a serious infection or any severe injury, including the having diseases which affect the kidney, liver or thyroid. If they have type 1 diabetes, or have been scheduled to undergo any type of surgery, including dental procedures, they should inform their doctor, as well. For these cases, it will be necessary to have a dosage adjustment, and the patient's condition monitored during the course of treatment.

It is still not known whether taking Glyburide during pregnancy will harm the fetus. Pregnant patients will have to consult their doctor before taking the medication if they are pregnant, get pregnant, or plan to become pregnant during treatment. Glyburide may also be secreted into breast milk, and breastfeeding patients should refrain from taking this drug without first talking to their doctor.

Diabetes sufferers who have reached 65 years or older will require lesser doses of Glyburide as the drug causes a stronger reaction in their systems.

Avoiding smoking and alcoholic beverages, following a strict diet, and exercising regularly affect the patient's blood sugar levels in a positive way. It is also advisable to consult the doctor before starting any prescription or over-the-counter medications for cough, pain, allergies or weight loss while on Glyburide therapy.

Other medications that may alter the efficacy of Glyburide include antibiotics, anticoagulants, dexamethasone, diuretics, oral contraceptives, estrogens, tranylcypromine, phenytoin, prednisnone, MAO inhibitors, metformin, probenecid, and drugs used to treat high blood pressure and cardiovascular disease. Patients should inform their doctor about any other medicines or vitamin and herbal supplements they are taking.

Glyburide may cause photosensitivity, and patients taking this drug will need to wear sunscreen, protective clothing and eyewear, and avoid being exposed to sunlight for long periods of time.

Side effects of taking this medication will exhibit themselves as erratic blood sugar levels (either too high or too low). Symptoms of hypoglycemia or low blood sugar include tremors, headaches, anxiety, paleness and weakness, mood swings, cold sweat and pale skin. Hyperglycemia or high blood sugar will cause the patient to have increased urination and to be constantly hungry and thirsty. Patients should call their doctor immediately once they experience these symptoms, as these may develop into even more serious complications if not treated immediately.

Other serious side effects which will necessitate medical attention include fever, a skin rash, serious sunburn, jaundice, dark urine, light-colored stools, and unexplained bruising or bleeding.

Glyburide can be purchased with a prescription and it is available in the market under the brands Diabeta, Glynase and Micronase. Each tablet dose is taken with a glass of water, once a day before breakfast.

Patients will also do well to remember that taking Glyburide is not without risks. Studies have shown that taking oral diabetes medication increases a person's chance of succumbing to heart disease, as compared to managing the disease through diet alone, with or without insulin treatments.

Glyburide has the following structural formula:

Chemical structure of glyburide

• Molecular formula of glyburide is C23H28ClN3O5S
• Chemical IUPAC Name is 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide
• Molecular weight is 494.004 g/mol
Glyburide available : 1.25mg tablets, 2.5mg tablets, 5mg tablets

Brand name(s): Abbenclamide, Adiab, Azuglucon, Bastiverit, Benclamin, Betanase, Calabren, Cytagon, Daonil, Debtan, Dia-basan, Diabeta, Diabiphage, Dibelet, Duraglucon, Euclamin, Euglucan, Euglucon, Euglykon, Gen-Glybe, Gewaglucon, Gilemal, Glamide, Glibadone, Gliban, Gliben, Glibenbeta, Glibenclamida, Glibenclamide, Glibenclamidum, Glibenil, Glibens, Glibesyn, Glibet, Glibetic, Glibil, Gliboral, Glicem, Glidiabet, Glimel, Glimide, Glimidstata, Glisulin, Glitisol, Glubate, Gluben, Gluco-Tablimen, Glucobene, Glucohexal, Glucolon, Glucomid, Glucoremed, Glucoven, Glyben, Glybenclamide, Glybenzcyclamide, Glycolande, Glycomin, Glynase, Hemi-Daonil, Hexaglucon, Humedia, Lederglib, Libanil, Lisaglucon, Malix, Maninil, Med-Glionil, Melix, Micronase, Miglucan, Nadib, Neogluconin, Normoglucon, Novo-Glyburide, Orabetic, Pira, Praeciglucon, PresTab, Prodiabet, Renabetic, Sugril, Suraben, Tiabet, Yuglucon

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