Halobetasol propionate
Halobetasol propionate

Halobetasol propionate review

Halobetasol propionate, or halobetasol, belongs to a class of topical corticosteroid drugs. The main action of this drug is to reduce the chemicals responsible in inflammation, swelling and redness of the skin.

Corticosteroids are synthetic steroid hormone drugs produced in the adrenal cortex. They are involved in various physiological systems such as stress and immune response, regulation of metabolism, catabolism, electrolyte levels, inflammation and even behavior.

Halobetasol propionate, sold under the trade name Ultravate cream, is a topical corticosteroid cream indicated for use in the treatment of inflammation and itching caused by various skin conditions, including allergic reactions, psoriasis and eczema.

Halobetasol propionate cream, or Ultravate cream contains 0.05% halobetasol propionate. Ultravate is supplied in the following tube sizes: 15 grams and 50 grams.

Halobetasol propionate cream is a very potent topical corticosteroid. The recommended use of the cream should only be limited to two weeks, and the amount used should not be greater than 50 grams per week. If within two weeks and no improvement is shown, the use of the drug is to be discontinued.

The most commonly reported side effects of the drug are allergic reactions to the cream. Allergic reactions reported were itching, stinging and burning. Some patients have also reported dry skin, skin atrophy, erythema, rashes, and even leukoderma.

Other side effects reported from the use of high potency corticosteroid creams include acne formations and eruptions, hypopigmentation, folliculitis, perioral dermatitis, secondary infections, and miliaria.

Halobetasol propionate is contraindicated in patients with a known hypersensitivity to the drug or its known components. It is contraindicated in patients with hypersensitivity to high potency corticosteroids, or corticosteroids in general.

The systemic absorption of corticosteroids may produce reversible suppression in the hypothalamic pituitary adrenal axis, coupled with gluccocorticosteroid insufficiency once the patient stops treatment. Caution is to be advised when administering the cream, as some patients may also manifest symptoms of Cushing’s syndrome, glucosuria, and hyperglycemia due to systemic absorption.

Exercise caution when administering the cream to pediatric patients as they may become more susceptible to systemic toxicity due to the larger ratios of their skin surfaces to body mass. Geriatric patients may be more sensitive to the drug reactions.

During halobetasol treatment, if concomitant infections develop, appropriate antifungal or antibacterial therapy should be used. Halobetasol is not to be used in the treatment of rosacea or perioral dermatitis. The halobetasol propionate cream should only be used in the skin, and not on the face, eyes, axillae, or on the groin.

It is not known whether guaifenesin has adverse effects to the fetus. However, the use of the drug in pregnant women should always be consulted with the doctor. Clinical studies have shown that there have been traces of halobetasol in human milk, which may affect or suppress the growth of the infant. Nursing mothers, or women planning to breastfeed, must first consult their doctor prior to the usage of the drug. The potential benefits of the drug must always be weighed against its risks to the nursing mother and infant.

Halobetasol propionate has the following structural formula:

Chemical structure of halobetasol propionate

• Molecular formula of halobetasol propionate is C25H31ClF2O5
• Chemical IUPAC Name is [17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] propanoate
• Molecular weight is 484.96 g/mol
Halobetasol propionate available : 0,05% cream

Generic name: Halobetasol propionate

Brand name(s): Ulobetasol Propionate, Ultravate

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