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Hexalen

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Hexalen

Hexalen review





Hexalen is an antineoplastic that is used to treat refractory ovarian cancer. It isn't regarded as a first-line treatment for the illness and is instead used as salvage therapy. It has the major benefit of not being as toxic as other medicaments currently being used to treat refractory ovarian cancer. Hydroxymethylmelamines are the active metabolite for this medicament. Hexalen was approved for use by the Food and Drug Administration in 1990.

Hexalen is recommended for patients with refractory ovarian cancer that has persisted or recurred after treatment with other anti-cancer medicaments. It has also been used to treat lung cancer. At present, this agent's precise mechanism of action and the reason behind its anti-cancer effect is unknown, but MeSH (Medical Subject Headings) has nevertheless classified it as an alkylating antineoplastic agent.

The patient's height and weight are used in determining the proper dose of Hexalen. This medicament should be taken orally as instructed by your physician. It's usually taken at bedtime and after meals. You should not increase your dose, take it more frequently than necessary, or halt treatment without first consulting with your physician.

This medicine may be administered for two or three consecutive weeks as part of one or more twenty-eight day cycles. The recommended daily dose of Hexalen is typically split into four oral doses taken after breakfast, lunch, dinner, and before bedtime.

The most common side effect of Hexalen is emesis and gradual-onset nausea. Central nervous system symptoms include vertigo, dizziness, ataxia, disorders of consciousness, mood disorders and peripheral neuropathy symptoms include tingling and numbness because of the abnormal function of the sensory nerves of the legs and arms. These symptoms appear to be reversible. Seek immediate medical attention if you develop symptoms of blood disorders or nervous system problems such as the tingling of your hands or feet, mood changes, loss of coordination, easy bruising or bleeding, or persistent fever or acute pharyngitis.

Note that taking Hexalen may cause platelet and white blood cell counts to decrease, which increase the risk of bleeding and infection respectively.

Before taking this medicament, be sure to inform your physician if you have any allergies (especially medical allergies), blood disorders, nervous system illness, and seizure disorders. If after taking this medicament you suffer from dizziness, practice caution when operating heavy machinery or driving. You should also be careful when climbing stairs or rising from a seated position.

Blood tests and nervous system tests must first be conducted on a patient before starting treatment because Hexalen has been known to cause blood problems like thrombopenia and bone marrow suppression and nervous system problems. Blood tests must be conducted monthly during Hexalen therapy.

Women who are pregnant are discouraged from taking Hexalen. Ask your physician for more information in regards to pregnancy and Hexalen use. Currently, it is not known if this medicament passes into breast milk, so it would be best for nursing mothers to stop breastfeeding while undergoing Hexalen therapy. Consult your physician for more details.

Hexalen may cause a severe sudden decrease in blood pressure upon standing when given to patients undergoing antidepressant therapy of the Monoamine oxidase inhibitor class. Also, Tagamet (cimetidine) may hamper the purging of Hexalen from your body, which may increase your risk of side effects. Vitamin B6 (pyridoxine) can reduce the risk of neurotoxicity, but can also reverse the beneficial effects of Hexalen in treating ovarian cancer.

Hexalen has the following structural formula:

Chemical structure of hexalen


• Molecular formula of hexalen is C9H18N6
• Chemical IUPAC Name is N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine
• Molecular weight is 210.28 g/mol
Hexalen available : 50mg capsules

Generic name: Altretamine

Brand name(s): Altretaminum, Hemel, Hexastat

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