Hexastat review

Hexastat is an antineoplastic used to treat refractory ovarian cancer. It isn't regarded as a first-line treatment for the disease but is instead used as salvage therapy. It has the major benefit of not being as toxic as other medicaments currently being used to treat refractory ovarian cancer. Hydroxymethylmelamines are the active metabolite for this medication. Hexastat was approved for use by the Food and Drug Administration in 1990.

Hexastat is recommended for patients with refractory ovarian cancer that has persisted or recurred after treatment with other anti-cancer medicaments. It has also been used to treat lung cancer. At present, this agent's precise mechanism of action and the reason behind its anti-cancer effect is unknown, but MeSH (Medical Subject Headings) has classified it as an alkylating antineoplastic agent.

The patient's height and weight are key in determining the proper dosage of Hexastat. This medication should be taken orally as instructed by your physician. It's usually taken at bedtime and after meals. You should not alter your dosage or stop taking the medication without first consulting your physician.

This medicine may be administered for two or three consecutive weeks as part of one or more twenty-eight day cycles. The recommended daily dosage of Hexastat is typically split into four oral dosages that are taken after breakfast, lunch, dinner, and before bedtime.

The most common side effect of Hexastat is emesis and gradual-onset wamble. Central nervous system symptoms include vertigo, dizziness, ataxia, disorders of consciousness, mood disorders and peripheral neuropathy symptoms include tingling and numbness because of the abnormal function of the sensory nerves of the legs and arms. These symptoms appear to be reversible. Seek immediate medical attention if you develop symptoms of blood disorders or nervous system problems such as the tingling of your hands or feet, mood changes, loss of coordination, easy bruising or bleeding, or persistent fever or acute pharyngitis. If after taking this medication you suffer from dizziness, practice caution when operating heavy machinery or driving. You should also be careful when climbing stairs or rising from a seated position.

Note that taking Hexastat may cause platelet and white blood cell counts to decrease, which increase the risk of bleeding and infection respectively.

Before taking this medication, be sure to inform your physician if you have any allergies (especially medical allergies), blood disorders, nervous system disease, and seizure disorders. Blood tests and nervous system tests must first be conducted on a patient before starting treatment because Hexastat has been known to cause blood problems like thrombopenia and bone marrow suppression and nervous system problems. Blood tests must be conducted monthly during Hexastat therapy.

Women who are pregnant are discouraged from taking Hexastat. Ask your physician for more information regarding pregnancy and Hexastat use. It is not currently known if this medication passes into breast milk, so it would be best for nursing mothers to stop breastfeeding while taking Hexastat. Consult your physician for more details.

Hexastat may cause a severe, sudden decrease in blood pressure upon standing when given to patients undergoing antidepressant therapy of the MAO inhibitor class. Also, Tagamet (cimetidine) may hamper the purging of Hexastat from your body, which may increase your risk of side effects. Vitamin B6 (pyridoxine) can reduce the risk of neurotoxicity, but can also reverse the beneficial effects of Hexastat in treating ovarian cancer.

Hexastat has the following structural formula:

Chemical structure of hexastat

• Molecular formula of hexastat is C9H18N6
• Chemical IUPAC Name is N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine
• Molecular weight is 210.28 g/mol
Hexastat available : 50mg capsules

Generic name: Altretamine

Brand name(s): Altretaminum, Hemel, Hexalen

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