a first generation antihistamine of the piperazine class that is also an H1 antagonist was first synthesized as early as the mid-1950s. The medicinal formulation of the drug was afterwards announced on August 4, 1956 issue of Chemistry Week. It is mostly used as an antihistamine for the treatment of irritations and itches, an oploid potentiator, an anxiolytic "for the treatment of anxiety", a weak analgesic by itself, and an antiemetic for the reduction of nausea
The most typical Hydroxine formulation is the 25 milligram white, capsule-shaped, and scored tablets of hydrochloride salt manufactured by UCB in the Netherlands. On the other hand
, the nigh-spherical dark-green tablet is the most commonly available version of the drug, with 25 and 100 milligram capsules being marketed. There's also a series of color-coded round tablets made by Mallinkrodt that comes in 25 milligram white tablets, 50 milligram orange tablets, and 100 milligrams blue tablets.
When treating pruritus
, the recommended daily dose for Hydroxine is 25 milligrams given three to four times each day. As for sedation purposes, 50 to 100 milligrams should be administered per sedation session. Tension and anxiety
are managed by 50 to 100 milligrams four times every day. Hydroxine can be taken with or without food and has a maximal effect of about 30 to 60 minutes after it is taken. The drug's effects typically last for four to six hours.
You must measure the liquid form of Hydroxine with a special, dose-measuring cup or spoon, and not a regular table spoon. Ask your pharmacist for a dose-measuring device if you don't have one. Lastly, you must store this medicine at room temperature away from heat and moisture.
Hydroxine is not an over the counter (OTC) drug in some countries, so you typically need a doctor's permission before being able to get it like many other similarly potent antihistamines. Then again, there are other countries that allow Hydroxine and all or most other antihistamines to be sold over the counter.
If you are allergic to Hydroxine or are pregnant, you should not use any drug based on it. If you have certain sicknesses and conditions, you may need special tests or a dose adjustment to be able to safely use this drug. Before you take Hydroxine, inform you healthcare specialist or pharmacist if you have asthma
, any breathing problems, epilepsy
or other seizure disorders, kidney
disease, enlarged prostrate or problems with urination
, thyroid disorder, stomach
ulcer, blockage in your stomach or intestines, heart
disease or high blood pressure
, or glaucoma
This medication is under FDA Pregnancy Category D, which means you must not take Hydroxine without telling your physician that you're pregnant. It will harm you unborn child. More to the point, you must warn your doctor if you're going to be pregnant during treatment or use effective birth control
to avoid conception while taking Hydroxine.
It is currently unknown whether Hydroxine passes into breast
milk or harm a nursing baby, so to err on the side of caution, you must not use this medicine without telling your doctor that you're breastfeeding a baby. Finally, the elderly will more likely suffer side effects from this drug than younger people, so due caution must be observed before taking this medicine if you're an older adult.
Hydroxine can cause side effect that may hamper your reactions or thinking. Practice prudence and caution when driving or doing anything that requires alertness and awareness while under Hydroxine treatment. Moreover, you should stop using this drug and contact your doctor immediately once you suffer from serious side effects like restless muscle movements in your eyes, tongue
, jaw, or neck, seizures, confusion
, and tremors
. Lastly, avoid drinking alcoholic beverage while undergoing treatment. Doing so can increase some of the side effects of this medicine.
Hydroxine has the following structural formula:
• Molecular formula of hydroxine is C21H27ClN2O2
• Chemical IUPAC Name is 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol
• Molecular weight is 374.904 g/mol
• Hydroxine available : 50mg/ml solution 1ml vial, 10mg/5ml syrup, 10mg tablets, 25mg tablets, 50mg tablets