I-Tropine review

I-Tropine is a tropane alkaloid obtained from Atropa belladonna (deadly nightshade), Datura stramonium (jimsonweed), Mandragora officinarum (mandrake), and other plants of the family Solanaceae. This versatile medicament is a secondary metabolite of the above plants and provides a variety of effects and uses. Classified as an anticholinergic medicament, it serves as a competitive antagonist for the muscarinic acetylcholine receptor. Also known as Atropen, this medicament derives its name from Greek Mythology and is named after Atropos, one of the three Fates.

On The World Health Organization's Essential Drugs List, I-Tropine is considered a core medicine. This is a list of minimum medical requirements for a basic healthcare system.

Adult dosages range from half a milligram to one milligram or five to ten milliliters of the 0.1 milligram/milliliter solution for antisialagogue and other antivagal effects, add two to three milligrams or twenty to thirty milliliters of the 0.1 milligram/milliliter solution as an antidote for organophosporous muscarinic poisoning.

When no IV is available, patients should use the endotracheal administration of I-Tropine. One to two milligrams diluted to a total of no more than ten milliliters of normal saline or sterile water is the suggested adult dosage of I-Tropine for endotracheal administration. Dosage intervals of one or two hours are most suitable for cases that are not serious or critical.

Special consideration must be given to all patients over forty years of age when administering I-Tropine Sulfate Injection (USP). Acute glaucoma may occur during I-Tropine treatment in susceptible patients. Patients with prostatic hypertrophy may experience complete urinary retention, convert partial organic pyloric stenosis into complete obstruction, or cause inspissation of bronchial secretions and formation of dangerous viscid plugs in patients with chronic lung illness. Due to these potentially dangerous conditions, make certain that you doctor is aware of your complete medical history before beginning any treatment with I-Tropine.

Even though the recurrent use of I-Tropine is crucial in patients suffering from coronary artery illness, the total dosage needs to stay at or below two to three (maximum 0.03 to 0.04 milligrams/kilograms) to prevent the harmful side effects of I-Tropine-caused tachycardia on myocardial oxygen demand.

Patients suffering from bradyasystolic cardiopulmonary arrest should be given a single milligram dosage of I-Tropine intravenously and repeated every three to five minutes until symptoms subside. Three milligrams (0.04 milligrams/kilograms) given intravenously is a completely vagolytic dosage in most patients. Also, the administration of less than 0.05 milligrams can produce a paradoxical bradycardia because of the peripheral or central parasympathomimatic effects of low dosage I-Tropine in some adults.

I-Tropine's two to three milligram dosage should be repeated no less than every twenty to thirty minutes when being used as an antidote until symptoms are significantly reduced or until signs of I-Tropine poisoning occur. The initial dosage of this medicament is usually around 0.01 to 0.03 milligrams/kilograms of body weight. Dosing information for children hasn't been well researched. As such, this medicament should not be used on a child without consulting with a doctor first.

Side effects include tachycardia, photophobia, blurred vision, and dryness of mouth. These symptoms commonly occur with chronic administration of therapeutic dosages. For patients living in a hot climate, Anhidrosis, heat intolerance, and impaired temperature regulation may also occur. Elderly patients may suffer urination difficulties and constipation. Occasional hypersensitivity, skin rashes, and exfoliation have also been reported. If you experience any of these symptoms, consult your doctor.

Side effects due to I-Tropine poisoning include ataxia, fatigue, tremor, restlessness, dizziness, thirst, hot and dry skin, difficulty swallowing, dilated pupils, and abnormality of heartbeat. In some cases, it may lead to coma, delirium, hallucinations, restlessness and excitement, and marked abnormality of heartbeat. Severe intoxication while receiving I-Tropine treatment can lead to circulatory collapse and depression. Patients need to avoid alcohol consumption while taking this medicament. Consult your doctor immediately if you experience any of these symptoms.

I-tropine has the following structural formula:

Chemical structure of i-tropine

• Molecular formula of i-tropine is C17H23NO3
• Chemical IUPAC Name is (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate
• Molecular weight is 289.369 g/mol
I-tropine available : 5ml 1% bottles

Generic name: Atropine

Brand name(s): Atnaa, Atropair, Atropen, Atropin, Atropina, Atropinol, Atropisol, Atrosulf, Equipin, Eyesules, Hyoscyamine, Isopto atropine, Minims atropine, Ocu-Tropine, Tropine tropate, Troyl tropate

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