Imidazole Carboxamide
Imidazole Carboxamide

Imidazole Carboxamide review

Imidazole Carboxamide, an alkylating agent, is a medication used for the treatment of cancer and is administered either through intravenous infusion or injection.

Imidazole Carboxamide is also available under the brand names DTIC-Dome, DIC, and DTIC. This medication is recommended for patients with metastatic malignant melanoma, fibrosarcomas, soft tissue sarcomas, rhabdomyosarcoma, neuroblastoma, islet cell carcinoma, and carcinoma of the thyroid.


Imidazole Carboxamide can be administered intravenously through cannula at the back of a hand or through a thin plastic tube placed beneath the skin and into a vein close to the collarbone. It can also be administered through a thin tube placed into a vein of the PICC line, or by infusion via the cannula. The infusion normally takes anywhere from 30 minutes to 2 hours.

The length of Chemotherapy and number of treatment cycles depend on the type of cancer being treated. It is normal for Imidazole Carboxamide to be taken with other chemotherapy medications.

The amount of Imidazole Carboxamide prescribed depends on numerous factors that include the overall health of the patient and the type of condition being treated.


Patients should know that their reaction to Imidazole Carboxamide might differ from the reactions of other patients. Some patients may experience minimal side effects, while others may experience more.

Patients taking Imidazole Carboxamide may feel sick while taking the medication. Nausea and vomiting may become apparent a couple of hours after administration of the medicine and can last for several days. Physicians usually prescribe anti-emetic medications to reduce these symptoms.

Imidazole Carboxamide can also lessen the body’s production of white blood cells. This results in the patient becoming more susceptible to infections and can become apparent a week after administration of Imidazole Carboxamide. After a few weeks, the number of white blood cells will steadily increase.

Imidazole Carboxamide can also lessen the number of platelets in the body, which leads to unexplained bleeding or bruising. Patients may suffer from blood spots, nosebleeds, and bleeding gums as a result.

Patients taking Imidazole Carboxamide may also experience a decreased production of red blood cells or anemia. This usually makes the patient feel exhausted and breathless.

Imidazole Carboxamide may also lead to a loss of appetite and abnormal hair loss. Other rare side effects include diarrhea, sensitivity to sunlight, pain at the injected area, sore ulcers, and flu-like symptoms.

Patients should immediately inform their physician if they experience any of these side effects or if they persist or worsen.


Before taking Imidazole Carboxamide, patients should inform their physician of any and all medications that they are taking, whether prescription, non-prescription or herbal medications. Patients should also avoid medications containing aspirin unless given approval by physicians.

It is not safe for patients to take any sort of immunization while taking Imidazole Carboxamide.


Imidazole Carboxamide may affect the fertility of the patient. Patients should discuss this with their physician before taking the medication. It is not advisable for patients to breast feed while taking Imidazole Carboxamide since it may be passed on to the infant through breast milk.

Imidazole carboxamide has the following structural formula:

Chemical structure of imidazole carboxamide

 Molecular formula of imidazole carboxamide is C6H10N6O
 Chemical IUPAC Name is 5-dimethylaminoazo-3H-imidazole-4-carboxamide
 Molecular weight is 182.183 g/mol
 Imidazole carboxamide available : 100mg tablets and 200mg tablets

Generic name: Dacarbazine

Brand name(s): Biocarbazine R, Dacarbazino, Dacarbazinum, Deticene

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