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Indinavir

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Indinavir

Indinavir review





Indinavir, or indinavir sulfate, is a generic name for a medication that also goes by the brand name Crixivan. It is administered in capsules in combination with antiretroviral agents for the treatment of the human immunodeficiency virus, or HIV. It works by reducing a person’s risk for contracting any of the secondary illnesses that those with HIV-AIDS often suffer from, and by lengthening the time that the HIV virus can be suppressed. Indinavir is not a cure for the HIV infection, and it cannot altogether stop you from getting a secondary, opportunistic infection or illness. It is also important to remember that it cannot keep the HIV virus from spreading through sexual contact or contaminated blood.

Some of the side effects of Indinavir include the redistribution of body fat, or a greater accumulation of body fat. You may also experience heart attack, chest pains, and disorders of the blood vessels in the brain. Other effects include abnormal liver function, liver failure or hepatitis, pancreatitis, jaundice, heartburn or gas pain, anemia, increased bleeding in people who already have hemophilia, diabetes or worsening of existing diabetes, excess blood sugar, allergic reactions, vsculitis, muscle pain, oral paralysis, depression, kidney failure, crystal deposits in the kidneys, and increased triglycerides and cholesterol.

There are eight identified drugs that should not be taken with Indinavir. These include antiarrhythmics, which can cause serious or life-threatening reactions; ergot derivatives, including migraine medications, which can result in life-threatening toxicity; sedatives or hypnotics, which can result in depression of the respiratory system, making it difficult for you to breathe, or an increase of the sedative effects; gastrointestinal motility agents, which can cause cardiac arrhythmias; neuroleptic agents, which can also cause cardiac arrhythmias; herbal products such as St. John’s Wort, which can inhibit the immune system even further; antimyobacterial medications, which can inhibit the immune system further and provoke the body to resist the effects of the Indinavir; HMG-CoA Reductase inhibitors, since these can put you at serious risk for myopathy; a protease inhibitor called Atananavir, because it is similar to Indinavir and can increase its effects.

Besides these eight drugs which are totally contra-indicated, there are several other drugs that should be monitored carefully if they are given with Indinavir. These include the HIV antiviral agents Delavirdine, Didanosine, Efevirenz, Nelfinavir, Nevirapine, Ritonavir, and Saquinavir. It also includes other drugs such as bepridil, lidocaine, anticonvulsants, carbamazepine, Phenobarbital, phenytoin, calcium channel blockers, dihydropyridine, clarithromycin, inhaled or nasal steroids, HMG-CoA reductase inhibitors, immunosuppressants, itraconazole, ketoconazole, rifabutin, Sildenafil, Tadalafil, antidepressants, Vardenafil, and Venlafaxine.

Indinavir is in Pregnancy Category C, which means that studies have not shown a negative effect on pregnancies or developing fetuses. However, because these studies have all been done on animals and not on humans, it is not recommended that you use Indinavir during pregnancy unless you and your doctor decide that the benefits outweigh the risks. It is not know whether Indinavir is excreted in breast milk, so the potential exists for negative effects on a nursing child. If you are breastfeeding, you should not take Indinavir.

Indinavir has the following structural formula:

Chemical structure of indinavir


• Molecular formula of indinavir is C36H47N5O4
• Chemical IUPAC Name is 1-[2-hydroxy-4-[(2-hydroxy-2,3-dihydro-1H-inden-1-yl)carbamoyl]-5-phenyl-pentyl]- 4-(pyridin-3-ylmethyl)-N-tert-butyl-piperazine-2-carboxamide
• Molecular weight is 613.79 g/mol
Indinavir available : 200mg capsules, 400mg capsules

Brand name(s): Compound J, Crixivan

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