Iprox review

Iprox has proven useful in the treatment of schizophrenia. It tends to cause serious side effects if used improperly. Be sure to know the third-line treatment regimen to improve mood the right and safe way.


Iprox is the generic name of the antipsychotic medication that blocks a number of receptors for neurotransmitters. It is primarily used to treat schizophrenia symptoms in patients who have not shown adequate results from other medications. Iprox belongs to a medication class called atypical antipsychotics, which alters the activity of substances and chemicals in the brain. The medication may appear under brand names like Clozaril, Gen-Clozapin, Fazaclo and Leponex.

The medication comes in pill form and should be taken orally. It has a number of side effects that are considered lethal, which explains why it was categorized under third line treatment. Iprox has been shown to be more helpful in treating schizophrenia symptoms compared to older antipsychotic medications. Other uses for this medication include treating suicidal patients, paranoid individuals, manic patients, insomniacs and those suffering from schizoid personality, and dementia of the Lewy-body-type.


Drowsiness is the most common side effect. Some patients may experience increased heart rate, headache, weight gain, sleepiness, tremor, increased salivation, abnormally low blood pressure, fever, blurred vision, difficulty urinating, costiveness and paralytic ileus. Some side effects may disappear after taking the medication for 2 to 3 days. In rare cases, the medication may cause extrapyramidal effects or sudden involuntary movements of the extremities, eyes and head. A serious side effect is agranulocytosis where white blood cell count drastically drops making the patient vulnerable to infection and other illnesses. Other rare side effects include seizures, myocarditis, jaundice, cardiomyopathy, pulmonary embolism, respiratory depression and chest pain. If you experience any of these, they should be reported to your physician right away.


Pregnant women and breastfeeding mothers should talk with their doctor before taking Iprox. The medication may interact negatively with various other medications including risperidone, cimetidine, epinephrine, quinidine, anti-seizure medications, phenytoin, sedatives, SSRIs or selective serotonin reuptake inhibitors and tranquilizers. Doctors should be fully informed about any herbal medicine or nutritional supplement that the patient is taking to avoid adverse reactions. Patients with known allergic reactions to the medication should not take it. Individuals with a history of liver disease, kidney problem, lung problem, abnormally low blood pressure, leukemia, hypertension, glaucoma, diabetes and mental disease should take the medication cautiously.

Iprox acts by binding to serotonergic and dopamine receptors particularly dopamine at D1, D2, D3 and D5 receptors. It is also a 5-HT1A receptor partial agonist, which in turn improves mood. Furthermore, it acts as an antagonist at various adrenergic, histaminergic and cholinergic receptors. Once Iprox is metabolized in the liver, it then binds to brain receptors improving dopamine and serotonin levels, which are responsible for mood. As a result patients will exhibit improvement from schizophrenic symptoms.


24 schizophrenic patients were given Iprox for a span of 16 weeks. The initial dose was 25 mg a day during the first week and amounts were increased every two weeks until patients took around 400 mg during the last 2 weeks. During the first 4 weeks, 14 patients showed significant improvement in symptoms. Another 6 patients improved during the next 4 weeks until 21 out of 24 were shown to be stable at the end of the study. These patients were provided with Iprox only after 2 other medications were rendered ineffective.


Iprox is a prescription medication and should only be purchased at legitimate pharmacies and clinics. There are sources that sell over the internet as well but consumers should make sure that these are authentic and certified. Consumers may ask for certification when buying online.

Avoid alcohol and tobacco products while taking Iprox since these may decrease the effectiveness or exacerbate drowsiness. Long-term use should also be monitored since tardive dyskinesia and agranulocytosis may result. Patients should expect results within the first 4 to 6 weeks but continuous improvements are possible over 6 months to 1 year.

Iprox has the following structural formula:

Chemical structure of iprox

 Molecular formula of iprox is C18H19ClN4
 Iprox available : 25mg tablets, 100mg tablets

Generic name: Clozapine

Brand name(s): Asaleptin, Clozapin, Clozaril, Leponex, Lepotex

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