Isosorbide dinitrate
Isosorbide dinitrate

Isosorbide dinitrate review

Isosorbide dinitrate is a type of nitrate. It widens the blood vessels, enabling the blood to easily flow through it as well as the heart to perform its functions.

Isosorbide dinitrate is prescribed for those who have angina resulting from coronary artery disease. The sublingual form of isosorbide dinitrate is more effective in the treatment of angina since the other forms such as extended release and sustained release are not fast enough to control the ailment.

It may also be used for the treatment of congestive heart failure.

Isosorbide dinitrate is known under the brand names Isochron, Dilatrate-SR, and Isordil Titradose.

This medication can be administered on a full or empty stomach. The sublingual tablet of isosorbide dinitrate is dissolved in the mouth. It must never be chewed or crushed.

The recommended dosage of the sublingual form of isosorbide dinitrate is 2.5 milligrams up to 10 milligrams. The extended release and sustained release capsules may be taken 1-2 times daily, with dosing of 40-80 milligrams. For the tablet forms, the dosing may range from 5 to 40 milligrams taken 2-3 times a day.

Isosorbide dinitrate is usually kept on hand every time so that patients can take it once angina attacks. Patients should refill their prescription before their medicines run out completely.

Patients must also take this medication regularly to lessen the chances of angina attack. They should not change brands of this medication, too, without consent from their physicians.

The most common side effect that patients using isosorbide dinitrate experience is headaches. This is usually related to the dose they take, as higher doses usually lead to more occurrences of headaches.

Headaches can be treated by taking aspirin or any anti-headache medication.

Patients may also suffer from flushing since isosorbide dinitrate widens the blood vessels. This medication can also cause decreased blood pressure when the user rises from a sitting stance.

Isosorbide dinitrate can also cause patients to feel dizzy, weak, or experience palpitations. It is recommended that patients slowly rise from a sitting stance to decrease the risks of such side effects.

In case any of these side effects persist or worsen, patients should immediately seek medical assistance from their physicians or pharmacists.

Before using isosorbide dinitrate, patients should tell their doctors their medical histories particularly if they have had liver and kidney disease in the past. They should also tell if they have had a heart attack, glaucoma, anemia, head injury, thyroid ailment, or drug allergies.

While using isosorbide dinitrate, it is recommended that patients refrain from taking alcohol since it can lead to low blood pressure.

Patients should not get up too quickly since it can result to them fainting. They should sit down when feeling dizzy. They should also be careful during hot days, when having a physical activity, or when standing for a long stretch.

Isosorbide dinitrate may interact with other medications such as drugs for impotence (tadalafil and sildenafil). Patients should inform their doctors if they are taking these medications before using isosorbide dinitrate.

Isosorbide dinitrate has the following structural formula:

Chemical structure of isosorbide dinitrate

• Molecular formula of isosorbide dinitrate is C6H8N2O8
• Chemical IUPAC Name is 4,8-dinitrooxy-2,6-dioxabicyclo[3.3.0]octane
• Molecular weight is 236.136 g/mol
Isosorbide dinitrate available : 5mg tablets and 40mg tablets

Brand name(s): Cardis, Carvanil, Carvasin, Cedocard, Claodical, Cornilat, Coronex, Corosorbide, Difutrat, Dilatrate, Dinitrosorbide, Emoper, Flindix, Harrical, Ismotic, Iso-Bid, Isochron, Isoket, Isordil, Isostat, Isotrate, Korodil, Lomilan, Maycor, Myorexon, Nitrosorbid, Nitrosorbide, Nitrosorbon, Nosim, Resoidan, Rifloc Retard, Rigedal, Sorbangil, Sorbidilat, Sorbidnitrate, Sorbislo, Sorbitrate, Sorbonit, Sorquad, Tinidil, Titradose, Vascardin, Vasodilat, Vasorbate, Xanyl

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