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Itraconazole

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Itraconazole

Itraconazole review





Itraconazole capsules are prescribed to treat and medicate fungal infections that originate in the lungs and spread throughout the body. Itraconazole capsules are also prescribed to cure fungal infections of the toenails and/or fingernails. There is also an available oral solution of Itraconazole and it is used to treat yeast infections of the throat and mouth and throat. Suspected fungal infections in patients with fever and other kinds of infection can also be treated by Itraconazole. This drug belongs to triazoles, a certain class of anti-fungals. It primarily works by slowing the growth of certain fungi that facilitate the spread of infection.

Itraconazole is taken by mouth and is available in capsule and solution or liquid form. Usually, the capsules are taken on a full stomach one to three times a day for at least 3 months. If Itraconazole capsules are used to treat fungal infections of the toenails or fingernails, they are usually prescribed to be taken at least twice a day for seven days. An Itraconazole solution is usually prescribed by doctors to be taken on an empty stomach at least once or twice a day for one month or more.

Some doctors may tell their patients to take itroconazole capsules with carbonated drinks such as cola and soda if they are aware that their patient(s) is suffering from the following medical conditions or taking the following medications: famotidine (Pepcid); cimetidine (Tagamet); proton-pump inhibitors; nizatadine (Axid); proton-pump inhibitors such as lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (AcipHex) and omeprazole (Prilosec); or ranitidine (Zantac).

To use itraconazole oral solution for mouth-related fungal infections, gargle 2 teaspoons (10 ml) of the solution in the mouth for a few moments and swallow. Take note that it is not advisable to substitute capsules for liquid solution and vice versa.

You should inform your doctor or pharmacist if you are allergic to Itraconazole so that no health problems or complications will arise. If you are taking other anti-fungal medications such as ketoconazole (Nizoral), fluconazole (Diflucan), voriconazole (Vfend) or any other medications, tell your doctor so that the medication can be adjusted appropriately so as not to clash with other drugs.

If you have taken Itraconazole for the past few months, do not forget to mention it to your doctor because the effect of the drug can stay in the body for several months after intake. If you need to take an antacid while you are on Itraconazole medication, take it 1 or 2 hours before you take Itraconazole. If you have ever had or have cystic fibrosis, AIDS, or any condition that decrease the amount of acid in the stomach, you should tell your doctor so that proper medical attention can be given and adjustments can be done to your medication.

Some side effects of Itraconazole include diarrhea or loose stools, unusual dreams, constipation, runny nose, gas, depression, stomach pain, nervousness, heartburn, decreased sexual desire or activity, bleeding gums, muscle pain, etc.

More serious side effects of Itraconazole that needs special and immediate attention of doctors include excessive tiredness, yellowing of the eyes and skin, vomiting,rashes, hives, and difficulty breathing or swallowing.

Itraconazole has the following structural formula:

Chemical structure of itraconazole


• Molecular formula of itraconazole is C35H38Cl2N8O4
• Chemical IUPAC Name is 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3- dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2- (1-methylpropyl)-2,4-dihydro-1,2,4-triazol-3-one
• Molecular weight is 705.633 g/mol
Itraconazole available : 100mg capsules

Brand name(s): Itraconazol, Itraconazolum, Itrizole, Oriconazole, Sporal, Sporanos, Sporanox, Sporonox, Triasporn

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