has proven to be as potent and safe as erythromycin
. It is also more active in treating bacteria of other types that other alternative antibiotics may not be able to handle. The adverse reactions and drug interactions should also be considered to realize maximum effects.
Klacid is the generic name of the macrolide antibiotic used for the treatment and prevention of infections known or suspected to be caused by bacteria. It is used as an alternative drug if erythromycin and other antibiotics are rendered ineffective. The medication is indicated for pharyngitis
, acute maxillary sinusitis
, chronic bronchitis
, mycobacterium avium complex and skin infections. It also comes in the brand names Biaxin
, Claripen, Claridar, Klaricid
Klacid comes in the form of tablets, extended-release tablets and oral suspension which should be taken orally. It can also be applied topically in gel or lotion form. Klacid is the same as erythromycin in terms of antimicrobial spectrum but is more effective against a number of gram-negative bacteria like Legionella pneumophila. Other strains included in its coverage are Streptococcus pneumoniae, Neisseria gonorrhea
and Haemophilus influenzae.
Side effects may also result from Klacid use but most of these are considered to be only mild or transient. Examples of noticeable adverse reactions are diarrhea
, facial swelling
, abdominal pain and discomfort and vomiting
. Of these, only 1% was reported to be severe. Uncommon side effects include dizziness
, motion sickness
, dry mouth
, nightmares, anxiety
, rash and abnormal taste and smell. The taste is described as metallic lasting for the entire time of drug consumption. Rare side effects include anaphylactic shock, jaundice, liver
problems and kidney failure
. All symptoms should be reported immediately to the doctor.
People with a history of allergies
should consult their physician first to avoid any anaphylactic reaction. Examples of anaphylactic symptoms are wheezing, difficulty breathing, rash, skin itching
, throat spasms and joint
or muscle pain
. Individuals with HIV
, liver or kidney problems should also take the medication cautiously. Pregnant women, breastfeeding mothers as well as those who plan to get pregnant should consult a physician first before taking Klacid. A number of drugs can also interact with the drug such as astemizole, cisapride
, ergotamine, terfenadine and ranitidine.
Klacid stops bacteria from growing and proliferating by interfering with protein synthesis. The drug binds to bacterial ribosome specifically the subunit 50S causing the inhibition of peptide translation. Although the drug is highly associated with erythromycin, Klacid is acid-stable and can be taken orally without having to protect it from gastric acids. The drug is actively transported to infection sites because of the high concentration in phagocytes.
30 patients in a clinical study were given Klacid and erythromycin in a span of 2 weeks. All patients were suffering from skin infection. 15 were given 250 mg of Klacid thrice a day while the rest were given 250 mg of erythromycin thrice a day. Within the first week, 8 patients on Klacid treatment showed improvement in condition while 6 patients from the erythromycin group improved. By the end of the second week, 13 patients from the Klacid group showed improvement while only 10 from the erythromycin group improved.
Klacid is available in most pharmacies and doctors’ clinics. It is important to observe the label and packaging of the medication to ensure that it is authentic and fresh. When ordering online, be certain to verify the source as well as legitimacy of the online drugstore.
Patients should never double the dose if they forget taking one. They should take one as soon as they remember. Do not abruptly discontinue drug consumption even if symptoms of infection are already absent to keep the body from developing resistance.
Klacid has the following structural formula:
• Molecular formula of klacid is C38H69NO13
• Chemical IUPAC Name is 6-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-14-ethyl-12, 13-dihydroxy-4-(5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yl)oxy-7-methoxy- 3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
• Molecular weight is 747.953 g/mol
• Klacid available : 125mg/5ml suspension 100ml bottle, 250mg/5ml suspension 100ml bottle, 125mg/5ml suspension 50ml bottle, 250mg/5ml suspension 50ml bottle, 250mg tablets, 500mg tablets