Lariam review

Lariam is a type of antimalarial drug used for the prevention and cure of malaria. It contains an ingredient known as mefloquine, which attacks the parasite called Plasmodium responsible for the development of malaria in the body.

Lariam is usually taken once a week, usually on the same day. Dosage usually is started a couple of weeks before going to an area where malaria is prevalent. It must be regularly taken during the rest of the stay and continued a month after departing from the area. Lariam is not fit for children under 3 months or those weighing five kilograms and under.

Women are advised use effective contraceptives in order to prevent pregnancy while taking Lariam, both during the treatment stage and at least three months after the treatment has been stopped. This is due to the fact that safety of the drug during the pregnancy may not be established yet.

However, mefloquine has been known to cause various side effects such as changes in mood and behavior, depression, anxiety, aggression, hallucinations, and agitation. Patients who experience such psychiatric side effects must stop taking Lariam and consult a physician immediately. For those traveling to places where malaria is prevalent, it is recommended that they take Lariam three weeks before departure so that alternative medicine can be prescribed in case side effects of the drugs appear. Likewise, Lariam has also caused side effects that impaired the physical and mental abilities of patients to safely operate machineries.

Other side effects of Lariam may include disturbed sleep, tremor of the hands, disturbance in vision, vertigo, headache, changes in the blood pressure, and palpitations. Patients can also suffer from chest pains, rashes, itches, dizziness, fits, asthenia, and sleepiness.

Also, Lariam should be taken with precaution particularly those suffering from reduced kidney functions, irregular heartbeats, and epilepsy. Individuals suffering from allergy to quinine should not use Lariam.

Women who are breastfeeding should also refrain from taking Lariam, as well as those with a history of psychiatric illnesses and convulsions. The safety of taking Lariam for pregnant women has yet to be established. However, most doctors recommend that pregnant women refrain from taking Lariam. Women who are not pregnant should also take contraception in order to prevent pregnancy while taking this medicine for the treatment and cure of malaria.

There is an increased likelihood of irregular heartbeat if Lariam is taken simultaneously with medicines such as halofantrine, antiarrhythmics, quinidine, verapamil, propranolol, antihistamines, antipsychotics, and tricyclic antidepressants.

Likewise, patients are at risk of getting more serious cases of convulsions if Lariam is taken while using the following drugs such as quinine, chloroquine, antiepileptics such as valproate, carbamazepine, and phenytoin.

Lariam can also weaken the effectiveness of vaccination for oral typhoid. In case oral typhoid vaccine is important, then the dosage schedule should be completed first before the patient takes Lariam. In case the patient is taking the Lariam, the vaccination should be scheduled at least 12 hours after the dosage of Lariam.

Lariam has the following structural formula:

Chemical structure of lariam

• Molecular formula of lariam is C17H16F6N2O
• Chemical IUPAC Name is [2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethanol
• Molecular weight is 378.3122 g/mol
Lariam available : 250mg tablets

Generic name: Mefloquine

Brand name(s): Mefloquinone

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