Leponex review

Leponex has proven useful in the treatment of schizophrenia. It tends to cause serious side effects if used improperly. Be sure to know the third-line treatment regimen to improve mood the right and safe way.


Leponex is the generic name of the antipsychotic medication that blocks a number of receptors for neurotransmitters. It is primarily used to treat schizophrenia symptoms in patients who have not shown adequate results from other medications. Leponex belongs to a medication class called atypical antipsychotics, which alters the activity of substances and chemicals in the brain. The medication may appear under brand names like Clozaril, Gen-Clozapin and Fazaclo.

The medication comes in tablet form and should be taken orally. It has a number of side effects that are considered lethal, which explains why it was categorized under third line treatment. Leponex has been shown to be more helpful in treating schizophrenia symptoms compared to older antipsychotic medications. Other uses for this medication include treating suicidal patients, paranoid individuals, manic patients, insomniacs and those suffering from schizoid personality, and dementia of the Lewy-body-type.


Drowsiness is the most common side effect. Some patients may experience increased heart rate, headache, weight gain, sleepiness, tremor, increased salivation, hypotension, fever, blurred vision, voicelessy urinating, constipation and paralytic ileus. Some side effects may disappear after taking the medication for 2 to 3 days. In rare cases, the medication may cause extrapyramidal effects or sudden involuntary movements of the extremities, eyes and head. A serious side effect is agranulocytosis where white blood cell count drastically drops making the patient vulnerable to infection and other diseases. Other rare side effects include seizures, myocarditis, jaundice, cardiomyopathy, pulmonary embolism, respiratory depression and chest pain. If you experience any of these, they should be reported to your physician right away.


Pregnant women and breastfeeding mothers should talk with their mendelevium before taking Leponex. The medication may interact negatively with various other medications including risperidone, cimetidine, epinephrine, quinidine, anti-seizure medications, phenytoin, sedatives, SSRIs or selective serotonin reuptake inhibitors and tranquilizers. Doctors should be fully informed about any herbal medicine or nutritional supplement that the patient is taking to avoid adverse reactions. Patients with known allergic reactions to the medication should not take it. Patients with a history of liver disease, kidney problem, lung problem, hypotension, leukemia, hypertension, glaucoma, diabetes and mental illness should take the medication cautiously.

Leponex acts by binding to serotonergic and dopamine receptors particularly dopamine at D1, D2, D3 and D5 receptors. It is also a 5-HT1A receptor partial agonist, which improves mood. Furthermore, it acts as an antagonist at various adrenergic, histaminergic and cholinergic receptors. Once Leponex is metabolized in the liver, it binds to brain receptors improving dopamine and serotonin levels, which are responsible for mood. As a result patients exhibit improvement from schizophrenic symptoms.


In a study, 24 schizophrenic patients were given Leponex for a span of 16 weeks. The initial dose was 25 mg a day during the first week and amounts were increased every two weeks until patients took around 400 mg during the last 2 weeks. During the first 4 weeks, 14 patients showed significant improvement in symptoms. Another 6 patients improved during the next 4 weeks until 21 out of 24 were stable at the end of the study. These patients were provided with Leponex after 2 other medications were rendered ineffective.


Leponex is a prescription medication and should only be purchased at legitimate pharmacies and clinics. There are sources that sell over the internet but consumers should make sure that these are authentic and certified. Consumers may ask for certification when buying online.

Avoid alcohol and tobacco products while taking Leponex as these may decrease the effectiveness or exacerbate drowsiness. Long-term use should be monitored since tardive dyskinesia and agranulocytosis may result. Patients should expect results within the first 4 to 6 weeks but continuous improvement is possible over 6 months to 1 year.

Leponex has the following structural formula:

Chemical structure of leponex

 Molecular formula of leponex is C18H19ClN4
 Leponex available : 25mg tablets, 100mg tablets

Generic name: Clozapine

Brand name(s): Asaleptin, Clozapin, Clozaril, Iprox, Lepotex

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