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Leucosulfan

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Leucosulfan

Leucosulfan review





Leucosulfan is a common cancer medication and is known to slow down the neoplastic activity of malignant cells. It is a generic and non-specific cell type alkylating antineoplastic agent that was initially created as a therapeutic medication for chronic myeloid leukemia and has been reclassified as a generic medication for cancer cells.

This medication controls the burden of tumor formation and significantly slows down metastasis of cancer cells to other regions in the body. It is not able to completely impede the progress of the cancer cells, as it is incapable of reversing the overall cellular aberration effects of the cancer cells. Cytogenic abnormalities still progress, but at a much slower rate than without the medication.

Leucosulfan is given to cancer patients susceptible to chemotherapy and medication induction therapy. The medication works on a cellular level by producing Guanine-guanine strands of genetic output as it attacks the carbon strand in the mesylate group in a malignant cancer cell. This has large success rates for the target cancer cell and results in an apoptotic state. The result may also decrease overall strength as massive cellular destruction on the target area is occurring, which is evidenced by destruction of normal cells, especially in bone marrows.

Leucosulfan is an alternative for non-operative stem cell transplantation, therefore increasing receptivity for an oncoming transplant of stem cells.

Cancer patients should have all of the proper information regarding the medication and the proper supervision and expertise of a qualified doctor.

Leucosulfan is a palliative medication in dosages of 60 micrograms per body weight in kilos, with a maximum of 4 milligrams per day. For treatment of Polycythemia vera, 4 to 6 milligrams is recommended per day over a period of 4 to 6 weeks. For thrombocythaemia, 2 to 4 milligrams per day is recommended. Conditioning therapeutic medication plans recommend about 3.5 to 4 milligram per body weight in kilos per day, given in four doses, totaling 14 to 16 milligrams per kilo body weight.

Side effects of Leucosulfan may include general toxicity leading to fibrosis in the pulmonary tract, seizures, wasting of the muscles and organs, and cases of liver malfunction and failure. For seizures, phenytoin medication may be used to lessen the occurrence.

Let your doctor know about any medications already being used to determine possible medication-to-medication interactions. Special consideration needs to be given to antifungal medications such as azole variants. This medication also is contraindicated with phenothiazines and other cancer medications such as cyclosporine.

If contraindications of medications is suspected or determined, take medication cautiously three days after last previous medication is used. Acetaminophen is not to be used in conjunction with Leucosulfan since it raises blood levels and may increase the risk of complicated hypertension.

Leucosulfan has the following structural formula:

Chemical structure of leucosulfan


• Molecular formula of leucosulfan is C6H14O6S2
• Chemical IUPAC Name is 1,4-bis(methylsulfonyloxy)butane
• Molecular weight is 246.304 g/mol

Generic name: Busulfan

Brand name(s): Busulfex, Busulphan, Busulphane, Buzulfan, Citosulfan, Mablin, Mielevcin, Mielosan, Mielucin, Milecitan, Mileran, Misulban, Mitosan, Mitostan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Sulphabutin

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