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Lexiva

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Lexiva

Lexiva review





Lexiva, developed by GlaxoSmithKline, was first approved by the Food and Drug Administration in 1999 to be used in treating patients with HIV. This was considered impossible with previous medical technology.

Lexiva is a protease inhibitor, which is an antiretroviral medicament or ARV used in treating people with HIV. Studies show that people with HIV over 4 years of age can be given this medicament. Lexiva is commonly used for people with a high viral load and low levels of CD4 Cell Counts. This is used to keep HIV patients healthy with every treatment.

The Lexiva capsule is taken orally with a full glass of water. Adults are typically prescribed 1,200mg twice a day. This was first tested using the 150mg capsules that are no longer manufactured today. Considering that the Lexiva capsule is no longer manufactured; patients with HIV can take fosamprevanir as a substitute.

Lexiva is approved for use along with ritonavir -- another protease inhibitor medicament. Dosage may include one of the following depending upon the advice of your doctor:


1. 100mg of ritonavir along with 600mg or 4 capsules of Lexiva; twice a day; or
2. 200mg of ritonavir (2 caps) along with 1,200mg (8 caps) of Lexiva; once a day.

Common side effects associated with Lexiva include diarrhoea, nausea, emesis, numbness around the mouth, rashes, and stomach pains. A small portion of the patients taking Lexiva suffers from serious skin reactions, such as the Stevens-Johnson syndrome or other allergic reactions to the medicament. Doctors prescribe over-the-counter medicaments to control some of these side effects. If you develop any of these symptoms or other symptoms, consult your doctor immediately.

People with an allergic reaction to sulfa medicaments might want to refrain from using Lexiva or seek the advice of a doctor if you plan to proceed with the treatment. Considering that Lexiva is a protease inhibitor, there are no records of problems occurring for people suffering from high-cholesterol levels unlike other medicaments in the same family.

Liquid-based Lexiva contains glycol that may cause some problems for infants under 4 years old, people suffering from kidney or liver problems, pregnant women, or those taking certain medicaments. Consult with your doctor if you fall into any of these categories.

There is a possibility that Lexiva will react with other medicaments or herbal supplements. Both medicaments in your system may trigger an overdose that could prove fatal to the patient or an underdose that will render the treatment useless.

In most cases, other ARV medicaments are said to interact adversely with Lexiva. Patients being treated with tuberculosis medicaments should avoid using this medicament. Medications to treat headaches and migraines, as well as those used for male impotences and to control heart rhythms should be avoided when being treated with Lexiva or vice versa.

As with other protease inhibitors, patients planning a treatment using Lexiva must consult with their doctor for a thorough physical and medical examination to avoid risks, as well as following the prescribed dosage to avoid contraindications and fatal reactions.

Lexiva has the following structural formula:

Chemical structure of lexiva


• Molecular formula of lexiva is C25H35N3O6S
• Chemical IUPAC Name is tetrahydrofuran-3-yl[3-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]- 1-benzyl-2-hydroxy-propyl]aminomethanoate
• Molecular weight is 505.628 g/mol
Lexiva available : 50mg capsules

Generic name: Amprenavir

Brand name(s): Agenerase

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