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Lodosin

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Lodosin

Lodosin review





Lodosin, also known as MK-486, is a decarboxylase inhibitor given to patients with Parkinsons disease. It is used with the medication Levodopa, which increases the amount of dopamine in the body.

Lodosin prevents Levodopa from breaking down before it reaches the central nervous system. Due to this, only a smaller dosage of Levodopa is needed, minimizing the medication's side effects like wamble and vomiting. Lodosin together with Levodopa are a combination used to treat Parkinson's disease, a degenerative disorder that affects the central nervous system, speech and motor skills.

By itself, Lodosin does not work. It is effective only when taken with Levodopa. Both are used for the treatment of the side effects of chlorpromazine (Thorazine), fluphenazine (Prolixin) and perphenazine (Trilafon), which can cause conditions that affect the muscles.

Lodosin can cause dizziness or drowsiness and should not be taken within two hours of driving a vehicle, operating heavy machinery, or any activity that involves a great amount of risk.

Patients taking antidepressant medications like isocarboxazid (Marplan) and phenelzine (Nardil), and anxiety medications like tranycypromine (Parnate) should inform their physician before starting Lodosin-Levodopa treatment. They should also tell their physician if they have narrow-angle glaucoma (an eye disease), or malignant melanoma (a kind of skin cancer).

Other medications that are known to affect Lodosin treatment include antacids, hypertension medications, medication used for the treatment of epilepsy like phenytoin (Dilantin), ethotoin (Peganone) and mephenytoin (Mesantoin), spasm medications like papaverine (Pavabid, Cerespan), and pyridoxine (Vitamin B6). Patients taking these medications will have to refrain from taking Lodosin or take an adjusted dosage and undergo monitoring while undergoing treatment.

Diabetic patients should be aware that Lodosin may affect the results of sugar and ketone urine tests. They should inform their physician if they are taking this medication.

Other conditions that need to be discussed before taking Lodosin include heart disease, hypertension or high blood pressure, arteriosclerosis (hardening of the arteries), irregular heartbeat, previous incidences of heart attack, respiratory diseases like asthma, liver disease, kidney ailments, hormonal diseases which affect the endocrine glands, gastrointestinal disorders such as ulcers, wide-angle glaucoma, depression and other similar psychiatric syndromes.

Patients who are pregnant, plan to become pregnant or become pregnant during treatment should inform their physician. The effects of Lodosin on the fetus are unknown, so it is advisable to use the medication with extreme caution. Patients who are breastfeeding should let their physician know before proceeding with treatment as Lodosin may also be passed into breast milk.

Lodosin, by itself, does not cause any side effects. However, when combined with Levodopa, the tandem may result in slight wamble, vomiting or loss of appetite, costiveness, dry mouth or blurry eyesight, hand spasms and muscle twitches, sleep difficulties, confusion or nightmares, anxiety, exhaustion, and darker sweat and urine.

If patients start experiencing severe allergic reactions like breathing difficulties or swelling of the facial tissues, hives, uncontrollable body movements, constant wamble, vomiting and diarrhea, irregular heartbeat, unexplainable mood swings and seizures, they should immediately stop taking Lodosin and seek emergency medical care as soon as possible.

Lodosin is distributed under the brand name Lodosyn and comes in round, orange 25 mg. tablets. In combination with Levodopa, it is also known as Sinemet, Parcopa and Stalevo. Lodosin should be taken as prescribed by the physician, usually together with Levodopa, for the medication to take effect.

Lodosin has the following structural formula:

Chemical structure of lodosin


• Molecular formula of lodosin is C10H14N2O4
• Chemical IUPAC Name is 3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid
• Molecular weight is 226.229 g/mol
Lodosin available : 10-100mg tablets, 25-250mg tablets, 25-100mg tablets

Generic name: Carbidopa

Brand name(s): Atamet, Carbidopum, Lodosyn, Sinemet

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