Lodosyn review

Lodosyn, also known as MK-486, is a decarboxylase inhibitor given to patients with Parkinsons disease. It is used with the medicament Levodopa, which increases the amount of dopamine in the body.

Lodosyn prevents Levodopa from breaking down before it reaches the central nervous system. Due to this, only a smaller dosage of Levodopa is needed, minimizing the medicament's side effects like nausea and emesis. Lodosyn together with Levodopa are a combination used to treat Parkinson's disease, a degenerative disorder that affects the central nervous system, speech and motor skills.

By itself, Lodosyn does not work. It is effective only when taken with Levodopa. Both are used for the treatment of the side effects of chlorpromazine (Thorazine), fluphenazine (Prolixin) and perphenazine (Trilafon), which can cause conditions that affect the muscles.

Lodosyn can cause dizziness or drowsiness and should not be taken within two hours of driving a vehicle, operating heavy machinery, or any activity that involves a great amount of risk.

Patients taking antidepressant medicaments like isocarboxazid (Marplan) and phenelzine (Nardil), and anxiety medicaments like tranycypromine (Parnate) should inform their physician before starting Lodosyn-Levodopa treatment. They should also tell their physician if they have narrow-angle glaucoma (an eye disease), or malignant melanoma (a kind of skin cancer).

Other medicaments known to affect Lodosyn treatment include antacids, hypertension medicaments, medicament used for the treatment of epilepsy like phenytoin (Dilantin), ethotoin (Peganone) and mephenytoin (Mesantoin), spasm medicaments like papaverine (Pavabid, Cerespan), and pyridoxine (Vitamin B6). Patients taking these medicaments will have to refrain from taking Lodosyn or take an adjusted dosage and undergo monitoring while undergoing treatment.

Diabetic patients should be aware that Lodosyn may affect the results of sugar and ketone urine tests. Due to this, they should inform their physician if they are taking this medicament.

Other conditions that need to be discussed with your doctor before taking Lodosyn include heart disease, hypertension or high blood pressure, arteriosclerosis (hardening of the arteries), irregular heartbeat, previous incidences of heart attack, respiratory diseases like asthma, liver disease, kidney ailments, hormonal diseases which affect the endocrine glands, gastrointestinal disorders such as ulcers, wide-angle glaucoma, depression and other similar psychiatric syndromes.

Patients who are pregnant, plan to become pregnant or become pregnant during treatment should inform their physician. The effects of Lodosyn on the fetus are unknown, so it is advisable to use the medicament with extreme caution. Patients who are breastfeeding should let their physician know before proceeding with treatment since Lodosyn may also be passed into breast milk and cause harm to a nursing infant.

Lodosyn does not cause any side effects. However, when combined with Levodopa, it may result in slight nausea, emesis or loss of appetite, constipation, dry mouth or blurry eyesight, hand spasms and muscle twitches, sleep difficulties, confusion or nightmares, anxiety, fatigue, and darker sweat and urine.

If patients experience severe allergic reactions like breathing difficulties or swelling of the facial tissues, hives, uncontrollable body movements, constant nausea, emesis and diarrhea, irregular heartbeat, unexplainable mood swings and seizures, they should immediately stop taking Lodosyn and seek emergency medical care as soon as possible.

Lodosyn comes in round, orange 25 mg. pills. In combination with Levodopa, it is also known as Sinemet, Parcopa and Stalevo. Lodosyn should be taken exactly as prescribed by the physician, usually with Levodopa, for the medicament to take effect.

Lodosyn has the following structural formula:

Chemical structure of lodosyn

• Molecular formula of lodosyn is C10H14N2O4
• Chemical IUPAC Name is 3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid
• Molecular weight is 226.229 g/mol
Lodosyn available : 10-100mg tablets, 25-250mg tablets, 25-100mg tablets

Generic name: Carbidopa

Brand name(s): Atamet, Carbidopum, Lodosin, Sinemet

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